S100A3

S100A3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesS100A3, S100E, S100 calcium binding protein A3
External IDsMGI: 1338849 HomoloGene: 2223 GeneCards: S100A3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.3Start153,547,329 bp[1]
End153,549,372 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6274

20197

Ensembl

ENSG00000188015

ENSMUSG00000001021

UniProt

P33764

P62818

RefSeq (mRNA)

NM_002960

NM_011310
NM_001355597
NM_001355600
NM_001355602

RefSeq (protein)

NP_002951

NP_035440
NP_001342526
NP_001342529
NP_001342531

Location (UCSC)Chr 1: 153.55 – 153.55 MbChr 3: 90.56 – 90.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene.[5][6]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000188015 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001021 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667.
  6. 1 2 "Entrez Gene: S100A3 S100 calcium binding protein A3".

Further reading

  • Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem. Sci. 21 (4): 134–40. doi:10.1016/S0968-0004(96)80167-8. PMID 8701470.
  • Föhr UG, Heizmann CW, Engelkamp D, et al. (1995). "Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein with high affinity for zinc". J. Biol. Chem. 270 (36): 21056–61. doi:10.1074/jbc.270.36.21056. PMID 7673133.
  • Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
  • Kizawa K, Uchiwa H, Murakami U (1996). "Highly-expressed S100A3, a calcium-binding protein, in human hair cuticle". Biochim. Biophys. Acta. 1312 (2): 94–8. doi:10.1016/0167-4889(96)00023-7. PMID 8672544.
  • Böni R, Burg G, Doguoglu A, et al. (1997). "Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions". Br. J. Dermatol. 137 (1): 39–43. doi:10.1111/j.1365-2133.1997.tb03698.x. PMID 9274623.
  • Groves P, Finn BE, Kuźnicki J, Forsén S (1998). "A model for target protein binding to calcium-activated S100 dimers". FEBS Lett. 421 (3): 175–9. doi:10.1016/S0014-5793(97)01535-4. PMID 9468301.
  • Ridinger K, Ilg EC, Niggli FK, et al. (1999). "Clustered organization of S100 genes in human and mouse". Biochim. Biophys. Acta. 1448 (2): 254–63. doi:10.1016/S0167-4889(98)00137-2. PMID 9920416.
  • Fritz G, Heizmann CW, Kroneck PM (1999). "Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model". Biochim. Biophys. Acta. 1448 (2): 264–76. doi:10.1016/S0167-4889(98)00138-4. PMID 9920417.
  • Hoyaux D, Decaestecker C, Heizmann CW, et al. (2000). "S100 proteins in Corpora amylacea from normal human brain". Brain Res. 867 (1–2): 280–8. doi:10.1016/S0006-8993(00)02393-3. PMID 10837826.
  • Fritz G, Mittl PR, Vasak M, et al. (2002). "The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution". J. Biol. Chem. 277 (36): 33092–8. doi:10.1074/jbc.M200574200. PMID 12045193.
  • Mittl PR, Fritz G, Sargent DF, et al. (2003). "Metal-free MIRAS phasing: structure of apo-S100A3". Acta Crystallogr. D. 58 (Pt 8): 1255–61. doi:10.1107/S0907444902008430. PMID 12136135.
  • Kizawa K, Troxler H, Kleinert P, et al. (2003). "Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles". Biochem. Biophys. Res. Commun. 299 (5): 857–62. doi:10.1016/S0006-291X(02)02744-4. PMID 12470658.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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