RnaG

RnaG sRNA
	Predicted secondary structure and sequence conservation of RnaG small RNA
Identifiers
Rfam	RF02550
Other data
Domain(s)	Bacteria
SO	0000077,0000370
PDB structures	PDBe

RnaG is a small regulatory non-coding RNA encoded by the virulence plasmid of Shigella flexneri, a Gram-negative pathogenic bacterium that causes human bacillary dysentery. It is a first regulatory RNA characterised in S. flexneri. The RNA is 450 nucleotides long (which makes it one of the largest regulatory sRNAs) and it contains a region with specific secondary structure that interacts with icsA (virG) mRNA and forms a transcription terminator. Acting as antisense, RnaG is transcribed from the complementary strand of its target, icsA mRNA.^[1] The activity of the incA protein is crucial for spreading of the bacterial pathogen in the host cells.^[2]

References

↑ Giangrossi, M. (2010). "A novel antisense RNA regulates at transcriptional level the virulence gene icsA of Shigella flexneri". Nucleic Acids Research. 38: 3362–3375. doi:10.1093/nar/gkq025. PMC 2879508. PMID 20129941.
↑ Bernardini, M.L. (1989). "Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin". Proc Natl Acad Sci U S A. 86: 3867–71. doi:10.1073/pnas.86.10.3867. PMC 287242. PMID 2542950.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Giangrossi, M. (2010). "A novel antisense RNA regulates at transcriptional level the virulence gene icsA of Shigella flexneri". Nucleic Acids Research. 38: 3362–3375. doi:10.1093/nar/gkq025. PMC 2879508. PMID 20129941.

[2] Bernardini, M.L. (1989). "Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin". Proc Natl Acad Sci U S A. 86: 3867–71. doi:10.1073/pnas.86.10.3867. PMC 287242. PMID 2542950.