RUFY1

RUFY1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRUFY1, RABIP4, ZFYVE12, RUN and FYVE domain containing 1
External IDsMGI: 2429762 HomoloGene: 23522 GeneCards: RUFY1
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q35.3Start179,550,558 bp[1]
End179,610,026 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80230

216724

Ensembl

ENSG00000284260
ENSG00000176783

ENSMUSG00000020375

UniProt

Q96T51

Q8BIJ7

RefSeq (mRNA)

NM_001040451
NM_001040452
NM_025158

NM_172557

RefSeq (protein)

NP_001035541
NP_001035542
NP_079434

NP_766145

Location (UCSC)Chr 5: 179.55 – 179.61 MbChr 11: 50.39 – 50.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene.[5][6] It is named after the RUN and FYVE domains it contains.

Interactions

RUFY1 has been shown to interact with BMX.[5]

References

  1. 1 2 3 ENSG00000176783 GRCh38: Ensembl release 89: ENSG00000284260, ENSG00000176783 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020375 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Yang J, Kim O, Wu J, Qiu Y (Aug 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.
  6. ↑ "Entrez Gene: RUFY1 RUN and FYVE domain containing 1".

Further reading

  • Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y (2001). "A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1637–42. doi:10.1073/pnas.031586998. PMC 29309. PMID 11172003.
  • Fouraux MA, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij WJ, van der Sluijs P, Pruijn GJ (2004). "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes". Mol. Biol. Cell. 15 (2): 611–24. doi:10.1091/mbc.E03-05-0343. PMC 329268. PMID 14617813.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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