RRAGB

RRAGB
Identifiers
AliasesRRAGB, RAGB, bA465E19.1, Ras related GTP binding B
External IDsMGI: 3038613 HomoloGene: 48396 GeneCards: RRAGB
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10325

245670

Ensembl

n/a

ENSMUSG00000041658

UniProt

Q5VZM2

Q6NTA4

RefSeq (mRNA)

NM_006064
NM_016656

NM_001004154

RefSeq (protein)

NP_006055
NP_057740
NP_001340940
NP_001340942

NP_001004154

Location (UCSC)n/aChr X: 153.14 – 153.17 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related GTP-binding protein B is a protein that in humans is encoded by the RRAGB gene.[4][5][6]

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. MTORC1 responds to amino acids via interaction with RAGB.[6]

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041658 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Schurmann A, Brauers A, Massmann S, Becker W, Joost HG (Jan 1996). "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases". J Biol Chem. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
  5. ↑ Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Feb 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". J Cell Sci. 111. ( Pt 1): 11–21. PMID 9394008.
  6. 1 2 "Entrez Gene: RRAGB Ras-related GTP binding B".

Further reading

  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–96. doi:10.1167/iovs.02-1099. PMID 12766061.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sekiguchi T, Hirose E, Nakashima N, et al. (2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.". J. Biol. Chem. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.


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