RPS6KA6

RPS6KA6
Identifiers
Aliases	RPS6KA6, PP90RSK4, RSK4, ribosomal protein S6 kinase A6, RSK-4, p90RSK6, S6K-alpha-6
External IDs	MGI: 1914321 HomoloGene: 22816 GeneCards: RPS6KA6
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 84,058,346 bp[1] End 84,187,907 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X E1 Start 111,388,192 bp[2] End 111,537,959 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • metal ion binding • ATP binding • magnesium ion binding • protein serine/threonine kinase activity • kinase activity • protein kinase activity • ribosomal protein S6 kinase activity Cellular component • cytoplasm • nucleolus • mitochondrion • cell nucleus • cytosol • fibrillar center • nucleoplasm Biological process • intracellular signal transduction • phosphorylation • protein phosphorylation • negative regulation of embryonic development • central nervous system development • negative regulation of mesoderm development • negative regulation of ERK1 and ERK2 cascade • signal transduction • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27330	67071
Ensembl	ENSG00000072133	ENSMUSG00000025665
UniProt	Q9UK32	Q7TPS0
RefSeq (mRNA)	NM_014496 NM_001330512	NM_025949
RefSeq (protein)	NP_001317441 NP_055311	NP_080225
Location (UCSC)	Chr X: 84.06 – 84.19 Mb	Chr X: 111.39 – 111.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomal protein S6 kinase, 90kDa, polypeptide 6 is a protein in humans that is encoded by the RPS6KA6 gene. ^[5]

This gene encodes a member of ribosomal S6 kinase family, serine-threonin protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010].

References

Further reading