ROBO4

ROBO4
Identifiers
AliasesROBO4, ECSM4, MRB, roundabout guidance receptor 4
External IDsMGI: 1921394 HomoloGene: 10397 GeneCards: ROBO4
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q24.2Start124,883,691 bp[1]
End124,898,500 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54538

74144

Ensembl

ENSG00000154133

ENSMUSG00000032125

UniProt

Q8WZ75

Q8C310

RefSeq (mRNA)

NM_001301088
NM_019055

NM_028783
NM_001309390

RefSeq (protein)

NP_001288017
NP_061928

NP_001296319
NP_083059

Location (UCSC)Chr 11: 124.88 – 124.9 MbChr 9: 37.4 – 37.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154133 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032125 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Huminiecki L, Bicknell R (November 2000). "In silico cloning of novel endothelial-specific genes". Genome Research. 10 (11): 1796–806. doi:10.1101/gr.150700. PMC 310981. PMID 11076864.
  6. ↑ "Entrez Gene: ROBO4 roundabout homolog 4, magic roundabout (Drosophila)".

Further reading

  • Schmucker D (September 2003). "Downstream of guidance receptors: entering the baroque period of axon guidance signaling". Neuron. 40 (1): 4–6. doi:10.1016/S0896-6273(03)00603-2. PMID 14527427.
  • Huminiecki L, Gorn M, Suchting S, Poulsom R, Bicknell R (April 2002). "Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis". Genomics. 79 (4): 547–52. doi:10.1006/geno.2002.6745. PMID 11944987.
  • Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY (September 2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Developmental Biology. 261 (1): 251–67. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
  • Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R (May 2005). "roundabout4 is essential for angiogenesis in vivo". Proceedings of the National Academy of Sciences of the United States of America. 102 (18): 6373–8. doi:10.1073/pnas.0408318102. PMC 1088354. PMID 15849270.
  • Seth P, Lin Y, Hanai J, Shivalingappa V, Duyao MP, Sukhatme VP (July 2005). "Magic roundabout, a tumor endothelial marker: expression and signaling". Biochemical and Biophysical Research Communications. 332 (2): 533–41. doi:10.1016/j.bbrc.2005.03.250. PMID 15894287.
  • Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
  • Gröne J, Doebler O, Loddenkemper C, Hotz B, Buhr HJ, Bhargava S (June 2006). "Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer". Oncology Reports. 15 (6): 1437–43. doi:10.3892/or.15.6.1437. PMID 16685377.
  • Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC (June 2007). "A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium". Circulation Research. 100 (12): 1712–22. doi:10.1161/01.RES.0000269779.10644.dc. PMID 17495228.
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