RNH1

RNH1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNH1, RAI, RNH, ribonuclease/angiogenin inhibitor 1
External IDsMGI: 1195456 HomoloGene: 2204 GeneCards: RNH1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.5Start494,512 bp[1]
End507,300 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6050

107702

Ensembl

ENSG00000276230
ENSG00000023191

ENSMUSG00000038650

UniProt

P13489

Q91VI7

RefSeq (mRNA)

NM_001172100
NM_001172101
NM_145135

RefSeq (protein)

NP_001165571
NP_001165572
NP_660117

Location (UCSC)Chr 11: 0.49 – 0.51 MbChr 7: 141.16 – 141.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene.[5]

References

  1. 1 2 3 ENSG00000023191 GRCh38: Ensembl release 89: ENSG00000276230, ENSG00000023191 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038650 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1".

Further reading

  • Zneimer SM, Crawford D, Schneider NR, Beutler B (1991). "Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization". Genomics. 8 (1): 175–8. doi:10.1016/0888-7543(90)90242-M. PMID 2081593.
  • Weremowicz S, Fox EA, Morton CC, Vallee BL (1991). "The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5". Genomics. 8 (4): 717–21. doi:10.1016/0888-7543(90)90260-2. PMID 2276743.
  • Lee FS, Vallee BL (1989). "Binding of placental ribonuclease inhibitor to the active site of angiogenin". Biochemistry. 28 (8): 3556–61. doi:10.1021/bi00434a061. PMID 2742853.
  • Bond MD, Vallee BL (1989). "Isolation of bovine angiogenin using a placental ribonuclease inhibitor binding assay". Biochemistry. 27 (17): 6282–7. doi:10.1021/bi00417a013. PMID 3064806.
  • Hofsteenge J, Kieffer B, Matthies R, et al. (1989). "Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats". Biochemistry. 27 (23): 8537–44. doi:10.1021/bi00423a006. PMID 3219361.
  • Lee FS, Fox EA, Zhou HM, et al. (1989). "Primary structure of human placental ribonuclease inhibitor". Biochemistry. 27 (23): 8545–53. doi:10.1021/bi00423a007. PMID 3219362.
  • Schneider R, Schneider-Scherzer E, Thurnher M, et al. (1989). "The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module". EMBO J. 7 (13): 4151–6. PMC 455125. PMID 3243277.
  • Shapiro R, Vallee BL (1987). "Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2238–41. doi:10.1073/pnas.84.8.2238. PMC 304624. PMID 3470787.
  • Kiyohara H, Menjo M (1984). "Ribonuclease and ribonuclease inhibitor in the human pancreas". Gastroenterol. Jpn. 18 (5): 468–73. PMID 6653993.
  • Nadano D, Yasuda T, Takeshita H, et al. (1994). "Purification and characterization of human brain ribonuclease inhibitor". Arch. Biochem. Biophys. 312 (2): 421–8. doi:10.1006/abbi.1994.1328. PMID 8037455.
  • Kobe B, Deisenhofer J (1994). "Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats". Nature. 366 (6457): 751–6. doi:10.1038/366751a0. PMID 8264799.
  • Papageorgiou AC, Shapiro R, Acharya KR (1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution". EMBO J. 16 (17): 5162–77. doi:10.1093/emboj/16.17.5162. PMC 1170149. PMID 9311977.
  • Gaur D, Swaminathan S, Batra JK (2001). "Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants". J. Biol. Chem. 276 (27): 24978–84. doi:10.1074/jbc.M102440200. PMID 11342552.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Fu P, Chen J, Tian Y, et al. (2005). "Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor". Cancer Gene Ther. 12 (3): 268–75. doi:10.1038/sj.cgt.7700742. PMID 15592448.
  • Iyer S, Holloway DE, Kumar K, et al. (2005). "Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor". J. Mol. Biol. 347 (3): 637–55. doi:10.1016/j.jmb.2005.01.035. PMID 15755456.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Johnson RJ, McCoy JG, Bingman CA, et al. (2007). "Inhibition of Human Pancreatic Ribonuclease by the Human Ribonuclease Inhibitor Protein". J. Mol. Biol. 368 (2): 434–49. doi:10.1016/j.jmb.2007.02.005. PMC 1993901. PMID 17350650.


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