RNF43

RNF43
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KNG
Identifiers
Aliases	RNF43, RNF124, URCC, ring finger protein 43, SSPCS
External IDs	MGI: 2442609 HomoloGene: 37742 GeneCards: RNF43
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	58,417,595 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	87,735,539 bp[2]
Gene ontology
Molecular function	• metal ion binding; • protein binding; • frizzled binding; • ubiquitin protein ligase activity; • ubiquitin-protein transferase activity; • transferase activity;
Cellular component	• integral component of membrane; • plasma membrane; • integral component of plasma membrane; • nuclear envelope; • endoplasmic reticulum membrane; • cell nucleus; • endoplasmic reticulum; • membrane;
Biological process	• negative regulation of Wnt signaling pathway; • Wnt signaling pathway; • Wnt receptor catabolic process; • protein ubiquitination; • stem cell proliferation; • ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	54894
	207742
	ENSG00000108375
	ENSMUSG00000034177
	Q68DV7
	Q5NCP0
	NM_001305544; NM_001305545; NM_017763
	NM_172448; NM_001363437
	NP_001292473; NP_001292474; NP_060233
	NP_766036; NP_001350366
	Wikidata
View/Edit Human	View/Edit Mouse

Ring finger protein 43 is a protein that in humans is encoded by the RNF43 gene. ^[5]

Function

The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000108375 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034177 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Ring finger protein 43". Retrieved 2018-02-21.

Yagyu R, Furukawa Y, Lin YM, Shimokawa T, Yamamura T, Nakamura Y (November 2004). "A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer". Int. J. Oncol. 25 (5): 1343–8. PMID 15492824.
Sugiura T, Yamaguchi A, Miyamoto K (April 2008). "A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95". Exp. Cell Res. 314 (7): 1519–28. doi:10.1016/j.yexcr.2008.01.013. PMID 18313049.
Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S (January 2011). "RNF43 interacts with NEDL1 and regulates p53-mediated transcription". Biochem. Biophys. Res. Commun. 404 (1): 143–7. doi:10.1016/j.bbrc.2010.11.082. PMID 21108931.
Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H (August 2012). "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors". Nature. 488 (7413): 665–9. doi:10.1038/nature11308. PMID 22895187.
Ryland GL, Hunter SM, Doyle MA, Rowley SM, Christie M, Allan PE, Bowtell DD, Gorringe KL, Campbell IG (February 2013). "RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary". J. Pathol. 229 (3): 469–76. doi:10.1002/path.4134. PMID 23096461.
Xing C, Zhou W, Ding S, Xie H, Zhang W, Yang Z, Wei B, Chen K, Su R, Cheng J, Zheng S, Zhou L (January 2013). "Reversing effect of ring finger protein 43 inhibition on malignant phenotypes of human hepatocellular carcinoma". Mol. Cancer Ther. 12 (1): 94–103. doi:10.1158/1535-7163.MCT-12-0672. PMID 23136185.
Jiang X, Hao HX, Growney JD, Woolfenden S, Bottiglio C, Ng N, Lu B, Hsieh MH, Bagdasarian L, Meyer R, Smith TR, Avello M, Charlat O, Xie Y, Porter JA, Pan S, Liu J, McLaughlin ME, Cong F (July 2013). "Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma". Proc. Natl. Acad. Sci. U.S.A. 110 (31): 12649–54. doi:10.1073/pnas.1307218110. PMC 3732970. PMID 23847203.
Zou Y, Wang F, Liu FY, Huang MZ, Li W, Yuan XQ, Huang OP, He M (November 2013). "RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer". Gene. 531 (1): 112–6. doi:10.1016/j.gene.2013.08.054. PMID 24001777.
Zebisch M, Xu Y, Krastev C, MacDonald BT, Chen M, Gilbert RJ, He X, Jones EY (2013). "Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin". Nat Commun. 4: 2787. doi:10.1038/ncomms3787. PMC 3905715. PMID 24225776.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000108375 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034177 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: Ring finger protein 43". Retrieved 2018-02-21.

RNF43

Function

References

Further reading