RNF41

RNF41
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF41, FLRF, NRDP1, SBBI03, ring finger protein 41
External IDsMGI: 1914838 HomoloGene: 4226 GeneCards: RNF41
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.3Start56,202,175 bp[1]
End56,221,933 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10193

67588

Ensembl

ENSG00000181852

ENSMUSG00000025373

UniProt

Q9H4P4

Q8BH75

RefSeq (mRNA)

NM_001242826
NM_005785
NM_194358
NM_194359

NM_001164237
NM_026259

RefSeq (protein)

NP_001229755
NP_005776
NP_919339
NP_919340

NP_001157709
NP_080535

Location (UCSC)Chr 12: 56.2 – 56.22 MbChr 10: 128.41 – 128.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.[5]

Function

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.[5]

Interactions

RNF41 has been shown to interact with USP8.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000181852 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025373 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: RNF41 ring finger protein 41".
  6. ↑ Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.

Further reading

  • Cao Z, Wu X, Yen L, Sweeney C, Carraway KL (2007). "Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1". Mol. Cell. Biol. 27 (6): 2180–8. doi:10.1128/MCB.01245-06. PMC 1820496. PMID 17210635.
  • Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S (2006). "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)". J. Biol. Chem. 281 (49): 38061–70. doi:10.1074/jbc.M606704200. PMID 17035239.
  • Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
  • Qiu XB, Markant SL, Yuan J, Goldberg AL (2004). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMC 380992. PMID 14765125.
  • Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
  • Qiu XB, Goldberg AL (2002). "Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14843–8. doi:10.1073/pnas.232580999. PMC 137506. PMID 12411582.
  • Diamonti AJ, Guy PM, Ivanof C, Wong K, Sweeney C, Carraway KL (2002). "An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2866–71. doi:10.1073/pnas.052709799. PMC 122439. PMID 11867753.
  • Abdullah JM, Li X, Nachtman RG, Jurecic R (2001). "FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors". Blood Cells Mol. Dis. 27 (1): 320–33. doi:10.1006/bcmd.2001.0390. PMID 11358394.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.


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