RNF34

RNF34
Identifiers
Aliases	RNF34, CARP-1, CARP1, RFI, RIF, RIFF, hRFI, ring finger protein 34
External IDs	MGI: 2153340 HomoloGene: 11839 GeneCards: RNF34
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	121,430,623 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	122,871,291 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• metal ion binding; • phosphatidylinositol phosphate binding; • p53 binding; • ubiquitin protein ligase binding; • protein binding; • ubiquitin protein ligase activity; • ubiquitin-protein transferase activity; • transferase activity;
Cellular component	• cytoplasm; • endomembrane system; • cell nucleus; • membrane; • plasma membrane; • nuclear speck; • nucleoplasm; • cytosol; • nuclear body;
Biological process	• negative regulation of signal transduction by p53 class mediator; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; • protein K48-linked ubiquitination; • negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; • apoptotic process; • regulation of oxygen metabolic process; • cellular response to cold; • protein ubiquitination; • proteasome-mediated ubiquitin-dependent protein catabolic process; • ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	80196
	80751
	ENSG00000170633
	ENSMUSG00000029474
	Q969K3
	Q99KR6
	NM_194271; NM_001256858; NM_025126
	NM_030564
	NP_001243787; NP_079402; NP_919247
	NP_085041
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.^[5]^[6]

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170633 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029474 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Sasaki S, Nakamura T, Arakawa H, Mori M, Watanabe T, Nagawa H, Croce CM (Jul 2002). "Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer". Oncogene. 21 (32): 5024–30. doi:10.1038/sj.onc.1205627. PMID 12118383.
1 2 "Entrez Gene: RNF34 ring finger protein 34".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6170–5. doi:10.1073/pnas.0307459101. PMC 395941. PMID 15069192.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sasaki S, Watanabe T, Konishi T, et al. (2005). "Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence". J. Exp. Clin. Cancer Res. 23 (3): 507–12. PMID 15595643.
Konishi T, Sasaki S, Watanabe T, et al. (2005). "Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells". Mol. Cancer Ther. 4 (5): 743–50. doi:10.1158/1535-7163.MCT-05-0020. PMID 15897238.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170633 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029474 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid12118383-5] Sasaki S, Nakamura T, Arakawa H, Mori M, Watanabe T, Nagawa H, Croce CM (Jul 2002). "Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer". Oncogene. 21 (32): 5024–30. doi:10.1038/sj.onc.1205627. PMID 12118383.

[entrez-6] 1 2 "Entrez Gene: RNF34 ring finger protein 34".

RNF34

References

Further reading