RNF20

RNF20
Identifiers
AliasesRNF20, BRE1, BRE1A, hBRE1, ring finger protein 20
External IDsMGI: 1925927 HomoloGene: 5571 GeneCards: RNF20
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q31.1Start101,533,851 bp[1]
End101,563,344 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

56254

109331

Ensembl

ENSG00000155827

ENSMUSG00000028309

UniProt

Q5VTR2

Q5DTM8

RefSeq (mRNA)

NM_019592

NM_001163263
NM_182999
NM_001356401

RefSeq (protein)

NP_062538

NP_001156735
NP_892044
NP_001343330

Location (UCSC)Chr 9: 101.53 – 101.56 MbChr 4: 49.63 – 49.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.[5][6][7][8][9]

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.[9]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000155827 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028309 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Kim J, Hake SB, Roeder RG (Dec 2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions". Mol Cell. 20 (5): 759–70. doi:10.1016/j.molcel.2005.11.012. PMID 16337599.
  6. ↑ Wood A, Schneider J, Dover J, Johnston M, Shilatifard A (Sep 2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p". J Biol Chem. 278 (37): 34739–42. doi:10.1074/jbc.C300269200. PMID 12876294.
  7. ↑ Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M (Oct 2008). "The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression". Genes Dev. 22 (19): 2664–76. doi:10.1101/gad.1703008. PMC 2559905. PMID 18832071.
  8. ↑ Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K (Feb 2009). "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor". Mol Biol Cell. 20 (3): 757–68. doi:10.1091/mbc.E08-09-0983. PMC 2633391. PMID 19037095.
  9. 1 2 "Entrez Gene: RNF20 ring finger protein 20".

Further reading

  • Lossos IS, Alizadeh AA, Eisen MB, et al. (2000). "Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas". Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10209–13. doi:10.1073/pnas.180316097. PMC 27813. PMID 10954754.
  • Slachta CA, Jeevanandam V, Goldman B, et al. (2000). "Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries)". J. Immunol. 165 (6): 3469–83. doi:10.4049/jimmunol.165.6.3469. PMID 10975868.
  • Lee J, Monson NL, Lipsky PE (2001). "The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing". J. Immunol. 165 (11): 6322–33. doi:10.4049/jimmunol.165.11.6322. PMID 11086069.
  • Rowley AH, Shulman ST, Spike BT, et al. (2001). "Oligoclonal IgA response in the vascular wall in acute Kawasaki disease". J. Immunol. 166 (2): 1334–43. doi:10.4049/jimmunol.166.2.1334. PMID 11145718.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, et al. (2003). "A conserved RING finger protein required for histone H2B monoubiquitination and cell size control". Mol. Cell. 11 (1): 261–6. doi:10.1016/S1097-2765(02)00826-2. PMID 12535538.
  • Wood A, Krogan NJ, Dover J, et al. (2003). "Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter". Mol. Cell. 11 (1): 267–74. doi:10.1016/S1097-2765(02)00802-X. PMID 12535539.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
  • Zhu B, Zheng Y, Pham AD, et al. (2006). "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation". Mol. Cell. 20 (4): 601–11. doi:10.1016/j.molcel.2005.09.025. PMID 16307923.


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