RNF19A

RNF19A
Identifiers
AliasesRNF19A, RNF19, ring finger protein 19A, RBR E3 ubiquitin protein ligase
External IDsMGI: 1353623 HomoloGene: 8501 GeneCards: RNF19A
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q22.2Start100,257,060 bp[1]
End100,336,218 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

25897

30945

Ensembl

ENSG00000034677

ENSMUSG00000022280

UniProt

Q9NV58

P50636

RefSeq (mRNA)

NM_001280539
NM_015435
NM_183419
NM_001353837
NM_001353838

NM_013923
NM_001357631

RefSeq (protein)

NP_001267468
NP_056250
NP_904355
NP_001340766
NP_001340767

NP_038951
NP_001344560

Location (UCSC)Chr 8: 100.26 – 100.34 MbChr 15: 36.24 – 36.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.[5][6][7]

The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies (LBs), neuronal inclusions characteristic of Parkinson's disease (PD). This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript variants encoding the same protein have been reported.[7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000034677 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022280 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G (Mar 2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem Biophys Res Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID 11237715.
  6. ↑ Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766.
  7. 1 2 "Entrez Gene: RNF19 ring finger protein 19".

Further reading

  • Niwa J, Ishigaki S, Hishikawa N, et al. (2002). "Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity". J. Biol. Chem. 277 (39): 36793–8. doi:10.1074/jbc.M206559200. PMID 12145308.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ito T, Niwa J, Hishikawa N, et al. (2003). "Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1". J. Biol. Chem. 278 (31): 29106–14. doi:10.1074/jbc.M302763200. PMID 12750386.
  • Hishikawa N, Niwa J, Doyu M, et al. (2003). "Dorfin Localizes to the Ubiquitylated Inclusions in Parkinson's Disease, Dementia with Lewy Bodies, Multiple System Atrophy, and Amyotrophic Lateral Sclerosis". Am. J. Pathol. 163 (2): 609–19. doi:10.1016/S0002-9440(10)63688-7. PMC 1868225. PMID 12875980.
  • Paces-Fessy M, Boucher D, Petit E, et al. (2004). "The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins". Biochem. J. 378 (Pt 2): 353–62. doi:10.1042/BJ20030786. PMC 1223961. PMID 14611647.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Takeuchi H, Niwa J, Hishikawa N, et al. (2004). "Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis". J. Neurochem. 89 (1): 64–72. doi:10.1046/j.1471-4159.2003.02289.x. PMID 15030390.
  • Ishigaki S, Hishikawa N, Niwa J, et al. (2005). "Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders". J. Biol. Chem. 279 (49): 51376–85. doi:10.1074/jbc.M406683200. PMID 15456787.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Huang Y, Niwa J, Sobue G, Breitwieser GE (2006). "Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin". J. Biol. Chem. 281 (17): 11610–7. doi:10.1074/jbc.M513552200. PMID 16513638.
  • Ishigaki S, Niwa J, Yamada S, et al. (2007). "Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity". Neurobiol. Dis. 25 (2): 331–41. doi:10.1016/j.nbd.2006.09.017. PMID 17157513.


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