RNAIII

RNAIII
Identifiers
Symbol RNAIII
Rfam RF00503
Other data
RNA type Gene
Domain(s) Bacteria
SO 0005836
PDB structures PDBe

RNAIII is a small RNA which is known to regulate the expression of many Staphylococcus aureus genes encoding exoproteins and cell wall associated proteins.[1] In S. aureus, RNAIII acts as the effector of the agr quorum sensing system and is transcribed from the P3 operon. The RNAIII transcript also contains the 26 amino acid delta-haemolysin gene (hld).[2] RNAIII regulates the expression of the transcription factor rot by blocking its translation. It has been suggested that RNAIII binds to the rot mRNA in an antisense fashion occluding the Shine-Dalgarno sequence.[3][4]

References

  1. ↑ Waters LS, Storz G (February 2009). "Regulatory RNAs in Bacteria". Cell. 136 (4): 615–28. doi:10.1016/j.cell.2009.01.043. PMC 3132550. PMID 19239884.
  2. ↑ Benito, Y; Kolb FA; Romby P; Lina G; Etienne J; Vandenesch F (2000). "Probing the structure of RNAIII, the Staphylococcus aureus agr regulatory RNA, and identification of the RNA domain involved in repression of protein A expression". RNA. 6 (5): 668&ndash, 679. doi:10.1017/S1355838200992550. PMC 1369947. PMID 10836788.
  3. ↑ Geisinger E, Adhikari RP, Jin R, Ross HF, Novick RP (2006). "Inhibition of rot translation by RNAIII, a key feature of agr function". Mol. Microbiol. 61 (4): 1038–48. doi:10.1111/j.1365-2958.2006.05292.x. PMID 16879652.
  4. ↑ Boisset S, Geissmann T, Huntzinger E, et al. (June 2007). "Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism". Genes Dev. 21 (11): 1353–66. doi:10.1101/gad.423507. PMC 1877748. PMID 17545468.

Further reading

  • Chevalier C, Boisset S, Romilly C, et al. (March 2010). Cheung A, ed. "Staphylococcus aureus RNAIII Binds to Two Distant Regions of coa mRNA to Arrest Translation and Promote mRNA Degradation". PLoS Pathog. 6 (3): e1000809. doi:10.1371/journal.ppat.1000809. PMC 2837412. PMID 20300607.
  • Coelho LR, Souza RR, Ferreira FA, Guimarães MA, Ferreira-Carvalho BT, Figueiredo AM (November 2008). "agr RNAIII divergently regulates glucose-induced biofilm formation in clinical isolates of Staphylococcus aureus". Microbiology. 154 (Pt 11): 3480–90. doi:10.1099/mic.0.2007/016014-0. PMID 18957601.
  • Queck SY, Jameson-Lee M, Villaruz AE, et al. (October 2008). "RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus". Mol. Cell. 32 (1): 150–8. doi:10.1016/j.molcel.2008.08.005. PMC 2575650. PMID 18851841.
  • Simonetti O, Cirioni O, Ghiselli R, et al. (June 2008). "RNAIII-Inhibiting Peptide Enhances Healing of Wounds Infected with Methicillin-Resistant Staphylococcus aureus". Antimicrob. Agents Chemother. 52 (6): 2205–11. doi:10.1128/AAC.01340-07. PMC 2415788. PMID 18391046.
  • Korem M, Gov Y, Kiran MD, Balaban N (October 2005). "Transcriptional Profiling of Target of RNAIII-Activating Protein, a Master Regulator of Staphylococcal Virulence". Infect. Immun. 73 (10): 6220–8. doi:10.1128/IAI.73.10.6220-6228.2005. PMC 1230921. PMID 16177293.
  • Han YH, Kim YG, Kim DY, Ha SC, Lokanath NK, Kim KK (April 2005). "The target of RNAIII-activating protein (TRAP) from Staphylococcus aureus: purification, crystallization and preliminary X-ray analysis". Biochim. Biophys. Acta. 1748 (1): 134–6. doi:10.1016/j.bbapap.2004.11.021. PMID 15752702.
  • Huntzinger E, Boisset S, Saveanu C, et al. (February 2005). "Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression". EMBO J. 24 (4): 824–35. doi:10.1038/sj.emboj.7600572. PMC 549626. PMID 15678100.
  • Chabelskaya, S; Bordeau, V; Felden, B (Apr 1, 2014). "Dual RNA regulatory control of a Staphylococcus aureus virulence factor". Nucleic Acids Research. 42 (8): 4847–58. doi:10.1093/nar/gku119. PMC 4005698. PMID 24510101.


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