RNA-OUT

RNA-OUT
	Predicted secondary structure and sequence conservation of RNA-OUT
Identifiers
Symbol	RNA-OUT
Rfam	RF00240
Other data
RNA type	Gene; antisense
Domain(s)	Bacteria
SO	0000644
PDB structures	PDBe

RNA-OUT is a non-coding RNA that is antisense to the RNA-IN non-coding RNA. Transposition of insertion sequence IS10 is regulated by an anti-sense RNA which inhibits transposase expression when IS10 is present in multiple copies per cell. IS10 antisense pairing is facilitated by the RNA-binding protein, Hfq. RNA-OUT consists of a stem-loop domain topped by a flexibly paired loop; the 5' end of the target molecule, RNA-IN, is complementary to the top of the loop, and complementarity extends for 35 nucleotides down one side of RNA-OUT.^[1]

References

↑ Kittle, JD; Simons RW; Lee J; Kleckner N (1989). "Insertion sequence IS10 anti-sense pairing initiates by an interaction between the 5' end of the target RNA and a loop in the anti-sense RNA". J Mol Biol. 210. doi:10.1016/0022-2836(89)90132-0.

External links

Page for RNA-OUT at Rfam

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[1] Kittle, JD; Simons RW; Lee J; Kleckner N (1989). "Insertion sequence IS10 anti-sense pairing initiates by an interaction between the 5' end of the target RNA and a loop in the anti-sense RNA". J Mol Biol. 210. doi:10.1016/0022-2836(89)90132-0.