REXO2

REXO2
Identifiers
AliasesREXO2, REX2, RFN, SFN, CGI-114, RNA exonuclease 2
External IDsMGI: 1888981 HomoloGene: 6447 GeneCards: REXO2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q23.2Start114,439,386 bp[1]
End114,450,279 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

25996

104444

Ensembl

ENSG00000076043

ENSMUSG00000032026

UniProt

Q9Y3B8

Q9D8S4

RefSeq (mRNA)

NM_015523

NM_024233
NM_001357501
NM_001357503
NM_001357505

RefSeq (protein)

NP_056338

NP_077195
NP_001344430
NP_001344432
NP_001344434

Location (UCSC)Chr 11: 114.44 – 114.45 MbChr 9: 48.47 – 48.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

REX2, RNA exonuclease 2 homolog (S. cerevisiae), also known as REXO2, is an enzyme which in humans is encoded by the REXO2 gene.[5][6][7]

Function

Nucleases are components of DNA and RNA metabolism that carry out functions in DNA repair, replication, and recombination and in RNA processing and degradation. SFN is a homolog of Orn, a 3-prime-to-5-prime exoribonuclease of E. coli that attacks the free 3-prime hydroxyl group on single-stranded RNA, releasing 5-prime mono-nucleotides in a sequential manner.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000076043 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032026 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: REXO2 REX2, RNA exonuclease 2 homolog (S. cerevisiae)".
  6. ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  7. ↑ Nguyen LH, Erzberger JP, Root J, Wilson DM (August 2000). "The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers". J. Biol. Chem. 275 (34): 25900–6. doi:10.1074/jbc.M002672200. PMID 10851236.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  • Nguyen LH, Erzberger JP, Root J, Wilson DM (2000). "The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers". J. Biol. Chem. 275 (34): 25900–6. doi:10.1074/jbc.M002672200. PMID 10851236.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ito S, Kita K, Zhai L, et al. (2006). "Involvement of human small fragment nuclease in the resistance of human cells to UV-C-induced cell death". Photochem. Photobiol. 80 (2): 281–5. doi:10.1562/2004-01-21-RA-051. PMID 15362935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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