REG4

REG4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesREG4, GISP, REG-IV, RELP, regenerating family member 4
External IDsMGI: 1914959 HomoloGene: 41671 GeneCards: REG4
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p12Start119,794,018 bp[1]
End119,811,660 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

83998

67709

Ensembl

ENSG00000134193

ENSMUSG00000027876

UniProt

Q9BYZ8

Q9D8G5

RefSeq (mRNA)

NM_032044
NM_001159352
NM_001159353

NM_026328

RefSeq (protein)

NP_001152824
NP_001152825
NP_114433

NP_080604

Location (UCSC)Chr 1: 119.79 – 119.81 MbChr 3: 98.22 – 98.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regenerating islet-derived protein 4 is a protein that in humans is encoded by the REG4 gene.[5][6][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000134193 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027876 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK (Apr 2001). "Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV". Biochim Biophys Acta. 1518 (3): 287–93. doi:10.1016/s0167-4781(00)00284-0. PMID 11311942.
  6. ↑ Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T (Nov 2002). "Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas". Int J Cancer. 103 (2): 185–93. doi:10.1002/ijc.10788. PMID 12455032.
  7. ↑ "Entrez Gene: REG4 regenerating islet-derived family, member 4".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kämäräinen M, Heiskala K, Knuutila S, et al. (2003). "RELP, a Novel Human Reg-Like Protein with Up-Regulated Expression in Inflammatory and Metaplastic Gastrointestinal Mucosa". Am. J. Pathol. 163 (1): 11–20. doi:10.1016/S0002-9440(10)63625-5. PMC 1868159. PMID 12819006.
  • Zhang Y, Lai M, Lv B, et al. (2003). "Overexpression of Reg IV in colorectal adenoma". Cancer Lett. 200 (1): 69–76. doi:10.1016/S0304-3835(03)00460-9. PMID 14550954.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gu Z, Rubin MA, Yang Y, et al. (2005). "Reg IV: a promising marker of hormone refractory metastatic prostate cancer". Clin. Cancer Res. 11 (6): 2237–43. doi:10.1158/1078-0432.CCR-04-0356. PMID 15788672.
  • Bishnupuri KS, Luo Q, Murmu N, et al. (2006). "Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas". Gastroenterology. 130 (1): 137–49. doi:10.1053/j.gastro.2005.10.001. PMID 16401477.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
  • Takehara A, Eguchi H, Ohigashi H, et al. (2006). "Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4". Cancer Sci. 97 (11): 1191–7. doi:10.1111/j.1349-7006.2006.00297.x. PMID 16918991.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.