RASA4

RASA4
Identifiers
AliasesRASA4, CAPRI, GAPL, RAS p21 protein activator 4
External IDsMGI: 1858600 HomoloGene: 5080 GeneCards: RASA4
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q22.1Start102,573,807 bp[1]
End102,616,757 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10156

54153

Ensembl

ENSG00000105808

ENSMUSG00000004952

UniProt

O43374

Q6PFQ7

RefSeq (mRNA)

NM_001079877
NM_006989

NM_001039103
NM_133914

RefSeq (protein)

NP_001073346
NP_008920

NP_001034192
NP_598675

Location (UCSC)Chr 7: 102.57 – 102.62 MbChr 5: 136.08 – 136.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.[5][6]

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates as GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105808 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004952 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Lockyer PJ, Kupzig S, Cullen PJ (Jul 2001). "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway". Curr Biol. 11 (12): 981–6. doi:10.1016/S0960-9822(01)00261-5. PMID 11448776.
  6. 1 2 "Entrez Gene: RASA4 RAS p21 protein activator 4".

Further reading

  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  • Minagawa T, Fukuda M, Mikoshiba K (2001). "Distinct phosphoinositide binding specificity of the GAP1 family proteins: characterization of the pleckstrin homology domains of MRASAL and KIAA0538". Biochem. Biophys. Res. Commun. 288 (1): 87–90. doi:10.1006/bbrc.2001.5740. PMID 11594756.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Liu Q, Walker SA, Gao D, et al. (2005). "CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+". J. Cell Biol. 170 (2): 183–90. doi:10.1083/jcb.200504167. PMC 1351313. PMID 16009725.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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