RAP1GDS1

RAP1GDS1
Identifiers
Aliases	RAP1GDS1, GDS1, SmgGDS, Rap1 GTPase-GDP dissociation stimulator 1
External IDs	MGI: 2385189 HomoloGene: 41422 GeneCards: RAP1GDS1
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	98,443,861 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	139,075,201 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein binding; • GTPase activator activity;
Cellular component	• cytosol; • extracellular exosome; • endoplasmic reticulum; • mitochondrion;
Biological process	• negative regulation of endoplasmic reticulum calcium ion concentration; • positive regulation of mitochondrial calcium ion concentration; • vascular smooth muscle contraction; • myosin filament assembly; • small GTPase mediated signal transduction; • positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	5910
	229877
	ENSG00000138698
	ENSMUSG00000028149
	P52306
	n/a
NM_001100426; NM_001100427; NM_001100428; NM_001100429; NM_001100430;
	NM_021159
	NM_001040690; NM_001286759; NM_145544; NM_001356388
NP_001093896; NP_001093897; NP_001093898; NP_001093899; NP_001093900;
	NP_066982
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.^[5]^[6]^[7]

Interactions

RAP1GDS1 has been shown to interact with KIFAP3,^[8] HRAS^[9] and RHOA.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138698 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028149 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. doi:10.1007/BF00420952. PMID 8262526.
↑ Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. doi:10.1074/jbc.M707526200. PMID 17951244.
↑ "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".
↑ Shimizu, K; Kawabe H; Minami S; Honda T; Takaishi K; Shirataki H; Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. UNITED STATES. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. ISSN 0021-9258. PMID 8900189.
1 2 Vikis, Haris G; Stewart Scott; Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. England. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. ISSN 0950-9232. PMID 11948427.

Kikuchi A, Kaibuchi K, Hori Y, et al. (1992). "Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21". Oncogene. 7 (2): 289–93. PMID 1549351.
Shimizu K, Kawabe H, Minami S, et al. (1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. PMID 8900189.
Vikis HG, Stewart S, Guan KL (2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. PMID 11948427.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
de Bruyn KM, Zwartkruis FJ, de Rooij J, et al. (2003). "The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes". J. Biol. Chem. 278 (25): 22412–7. doi:10.1074/jbc.M212036200. PMID 12690117.
Tiwari S, Felekkis K, Moon EY, et al. (2004). "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis". Blood. 103 (7): 2661–7. doi:10.1182/blood-2003-06-2154. PMID 14615375.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138698 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028149 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8262526-5] Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. doi:10.1007/BF00420952. PMID 8262526.

[pmid17951244-6] Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. doi:10.1074/jbc.M707526200. PMID 17951244.

[entrez-7] "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".

[pmid8900189-8] Shimizu, K; Kawabe H; Minami S; Honda T; Takaishi K; Shirataki H; Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. UNITED STATES. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. ISSN 0021-9258. PMID 8900189.

[pmid11948427-9] 1 2 Vikis, Haris G; Stewart Scott; Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. England. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. ISSN 0950-9232. PMID 11948427.

RAP1GDS1

Interactions

References

Further reading