RAP1GAP2

RAP1GAP2
Identifiers
AliasesRAP1GAP2, GARNL4, RAP1GA3, RAP1 GTPase activating protein 2
External IDsMGI: 3028623 HomoloGene: 56695 GeneCards: RAP1GAP2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.3Start2,755,705 bp[1]
End3,037,739 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23108

380711

Ensembl

ENSG00000132359

ENSMUSG00000038807

UniProt

Q684P5

Q5SVL6

RefSeq (mRNA)

NM_001100398
NM_015085
NM_001330058

NM_001015046
NM_001364131
NM_001364132

RefSeq (protein)

NP_001093868
NP_001316987
NP_055900

NP_001015046
NP_001351060
NP_001351061

Location (UCSC)Chr 17: 2.76 – 3.04 MbChr 11: 74.38 – 74.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.[5]

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132359 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038807 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: RAP1 GTPase activating protein 2".

Further reading

  • Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP (August 2009). "Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets". Blood. 114 (7): 1396–404. doi:10.1182/blood-2008-05-155234. PMID 19528539.
  • Aouizerat BE, Vittinghoff E, Musone SL, Pawlikowska L, Kwok PY, Olgin JE, Tseng ZH (June 2011). "GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease". BMC Cardiovascular Disorders. 11: 29. doi:10.1186/1471-2261-11-29. PMC 3141757. PMID 21658281.
  • Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, Bellora F, Perotti C, Balduini C, Balduini CL, Torti M (October 2004). "Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes". Experimental Cell Research. 300 (1): 84–93. doi:10.1016/j.yexcr.2004.07.011. PMID 15383317.
  • Kimura T, Mogi C, Sato K, Tomura H, Ohta H, Im DS, Kuwabara A, Kurose H, Murakami M, Okajima F (October 2011). "p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1". Cardiovascular Research. 92 (1): 149–58. doi:10.1093/cvr/cvr154. PMID 21632882.
  • Schultess J, Danielewski O, Smolenski AP (April 2005). "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets". Blood. 105 (8): 3185–92. doi:10.1182/blood-2004-09-3605. PMID 15632203.
  • Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP (January 2008). "Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets" (PDF). The Journal of Biological Chemistry. 283 (4): 2297–306. doi:10.1074/jbc.M706825200. PMID 18039662.
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