RAB38

RAB38
Identifiers
Aliases	RAB38, NY-MEL-1, rrGTPbp, member RAS oncogene family
External IDs	MGI: 1919683 HomoloGene: 21353 GeneCards: RAB38
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	88,175,467 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	88,491,572 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• AP-2 adaptor complex binding; • nucleotide binding; • BLOC-2 complex binding; • GTP binding; • GTP-dependent protein binding; • protein binding; • AP-3 adaptor complex binding; • AP-1 adaptor complex binding; • GTPase activity;
Cellular component	• cytoplasm; • vesicle; • phagocytic vesicle membrane; • Golgi apparatus; • membrane; • melanosome; • plasma membrane; • early endosome; • phagocytic vesicle; • endoplasmic reticulum; • early endosome lumen; • cytoplasmic vesicle; • lysosome; • mitochondrion; • ER-mitochondrion membrane contact site; • cytosol; • melanosome membrane; • trans-Golgi network;
Biological process	• protein localization to membrane; • platelet dense granule organization; • organelle organization; • phagosome acidification; • endosome to melanosome transport; • protein transport; • melanosome assembly; • mitochondrion organization; • vesicle-mediated transport; • small GTPase mediated signal transduction; • post-translational protein modification; • positive regulation of phosphatidylcholine biosynthetic process; • intracellular protein transport; • Rab protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23682
	72433
	ENSG00000123892
	ENSMUSG00000030559
	P57729
	Q8QZZ8
	NM_022337
	NM_028238
	NP_071732; NP_071732.1
	NP_082514
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-38 is a protein that in humans is encoded by the RAB38 gene.^[5]^[6]

In melanocytic cells RAB38 gene expression may be regulated by MITF.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123892 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030559 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.
↑ "Entrez Gene: RAB38 RAB38, member RAS oncogene family".
↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki T, Miyamura Y, Inagaki K, Tomita Y (2004). "Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA". J. Dermatol. Sci. 32 (2): 131–6. doi:10.1016/S0923-1811(03)00071-9. PMID 12850305.
Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Osanai K, Iguchi M, Takahashi K, et al. (2001). "Expression and Localization of a Novel Rab Small G Protein (Rab38) in the Rat Lung". Am. J. Pathol. 158 (5): 1665–75. doi:10.1016/S0002-9440(10)64122-3. PMC 1891947. PMID 11337364.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123892 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030559 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10910072-5] Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.

[entrez-6] "Entrez Gene: RAB38 RAB38, member RAS oncogene family".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

RAB38

References

Further reading