RAB22A

RAB22A
Identifiers
AliasesRAB22A, member RAS oncogene family
External IDsMGI: 105072 HomoloGene: 10782 GeneCards: RAB22A
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.32Start58,309,696 bp[1]
End58,367,507 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

57403

19334

Ensembl

ENSG00000124209

ENSMUSG00000027519

UniProt

Q9UL26

P35285

RefSeq (mRNA)

NM_020673

NM_024436

RefSeq (protein)

NP_065724

NP_077756

Location (UCSC)Chr 20: 58.31 – 58.37 MbChr 2: 173.66 – 173.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.[5]

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000124209 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027519 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: RAB22A RAB22A, member RAS oncogene family".

Further reading

  • Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–662. doi:10.1055/s-2007-978953. PMID 9918381.
  • Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–662. doi:10.1006/bbrc.1999.0651. PMID 10329441.
  • Opdam FJ, Kamps G, Croes H, et al. (2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur. J. Cell Biol. 79 (5): 308–316. doi:10.1078/S0171-9335(04)70034-5. PMID 10887961.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–871. doi:10.1038/414865a. PMID 11780052.
  • Kauppi M, Simonsen A, Bremnes B, et al. (2002). "The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking". J. Cell Sci. 115 (Pt 5): 899–911. PMID 11870209.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–4679. doi:10.1074/jbc.M311228200. PMID 14613930.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Weigert R, Yeung AC, Li J, Donaldson JG (2005). "Rab22a regulates the recycling of membrane proteins internalized independently of clathrin". Mol. Biol. Cell. 15 (8): 3758–3770. doi:10.1091/mbc.E04-04-0342. PMC 491835. PMID 15181155.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mesa R, Magadán J, Barbieri A, et al. (2005). "Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus". Exp. Cell Res. 304 (2): 339–353. doi:10.1016/j.yexcr.2004.11.017. PMID 15748882.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. doi:10.1126/science.1105776. PMID 15761153.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
  • Magadán JG, Barbieri MA, Mesa R, et al. (2006). "Rab22a regulates the sorting of transferrin to recycling endosomes". Mol. Cell. Biol. 26 (7): 2595–2614. doi:10.1128/MCB.26.7.2595-2614.2006. PMC 1430328. PMID 16537905.


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