Protein THEMIS

THEMIS
Identifiers
AliasesTHEMIS, C6orf190, C6orf207, GASP, SPOT, TSEPA, bA325O24.3, bA325O24.4, thymocyte selection associated
External IDsMGI: 2443552 HomoloGene: 72287 GeneCards: THEMIS
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q22.33Start127,708,072 bp[1]
End127,918,631 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

387357

210757

Ensembl

ENSG00000275122
ENSG00000172673

ENSMUSG00000049109

UniProt

Q8N1K5

Q8BGW0

RefSeq (mRNA)

NM_001010923
NM_001164685
NM_001164687
NM_001318531

NM_178666
NM_001305663

RefSeq (protein)

NP_001010923
NP_001158157
NP_001158159
NP_001305460

NP_001292592
NP_848781

Location (UCSC)Chr 6: 127.71 – 127.92 MbChr 10: 28.67 – 28.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein THEMIS is a protein that in humans is encoded by the THEMIS gene.[5][6][7]

Function

This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.[8]

The name

THEMIS is an acronym for thymocyte-expressed-molecule. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since the protein is important in deciding the fate of the T cell during development.[9]

References

  1. 1 2 3 ENSG00000172673 GRCh38: Ensembl release 89: ENSG00000275122, ENSG00000172673 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049109 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR (August 2009). "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nat. Immunol. 10 (8): 848–56. doi:10.1038/ni.1766. PMC 2757056. PMID 19597499.
  6. ↑ Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE (August 2009). "Themis, a T cell-specific protein important for late thymocyte development". Nat. Immunol. 10 (8): 840–7. doi:10.1038/ni.1768. PMC 2848698. PMID 19597498.
  7. ↑ Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ, Schwartz RH (August 2009). "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection". Nat. Immunol. 10 (8): 831–9. doi:10.1038/ni.1769. PMC 2908989. PMID 19597497.
  8. ↑ "Entrez Gene: thymocyte selection associated".
  9. ↑ Zielinska E (2009-11-01). "Six degrees of science". The Scientist.

Further reading

  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
  • Allen PM (2009). "Themis imposes new law and order on positive selection". Nat. Immunol. 10 (8): 805–6. doi:10.1038/ni0809-805. PMID 19621038.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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