Propyleneimine

Propyleneimine
Names
	IUPAC name 2-Methylaziridine
	Other names 1,2-Propylenimine
Identifiers
CAS Number	75-55-8;
3D model (JSmol)	Interactive image;
ChemSpider	6137;
ECHA InfoCard	100.000.799
EC Number	613-033-00-6
PubChem CID	6377;
RTECS number	CM8050000
UN number	1921 (inhibited)
	InChI InChI=1S/C3H7N/c1-3-2-4-3/h3-4H,2H2,1H3 Key: OZDGMOYKSFPLSE-UHFFFAOYSA-N; InChI=1/C3H7N/c1-3-2-4-3/h3-4H,2H2,1H3 Key: OZDGMOYKSFPLSE-UHFFFAOYAW;
	SMILES N1C(C)C1;
Properties
Chemical formula	C3H7N
Molar mass	57.10 g·mol−1
Appearance	Colorless, oily liquid[1]
Odor	ammonia-like[1]
Density	0.9 g/mL[2]
Melting point	−63 °C (−81 °F; 210 K)[2]
Boiling point	67 °C (153 °F; 340 K)[2]
Solubility in water	Miscible[2]
Vapor pressure	112 mmHg (20°C)[1]
Hazards
R-phrases (outdated)	R45-R11-R26/27/28-R41[2]
S-phrases (outdated)	S53-S45[2]
Flash point	−4 °C (25 °F; 269 K)[2]
	Lethal dose or concentration (LD, LC):
LCLo (lowest published)	500 ppm (rat, 4 hr)[3]
	US health exposure limits (NIOSH):
PEL (Permissible)	TWA 2 ppm (5 mg/m3) [skin][1]
REL (Recommended)	Ca TWA 2 ppm (5 mg/m3) [skin][1]
IDLH (Immediate danger)	Ca [100 ppm][1]
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Propyleneimine is the organic compound with the formula CH₃CH(NH)CH₂. It is a secondary amine]] and the smallest chiral aziridine (ring containing C₂N). It is a colorless liquid.

The compound is mainly of academic interest, e.g. for the synthesis of dendrimers, a process that exploits the tendency of aziridines to undergo ring-opening reactions.^[4] ^[2]

References

1 2 3 4 5 6 "NIOSH Pocket Guide to Chemical Hazards #0537". National Institute for Occupational Safety and Health (NIOSH).
1 2 3 4 5 6 7 8 Propyleneimine International Chemical Safety Card at actrav.itcilo.org
↑ "Propylene imine". Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
↑ Malik, N.; Wiwattanapatapee, R.; Klopsch, R.; Lorenz, K.; Frey, H.; Weener, J. W.; Meijer, E. W.; Paulus, W.; Duncan, R. (2000). "Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labeled polyamidoamine dendrimers in vivo". Journal of Controlled Release. 65: 133–148. doi:10.1016/S0168-3659(99)00246-1.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[PGCH-1] 1 2 3 4 5 6 "NIOSH Pocket Guide to Chemical Hazards #0537". National Institute for Occupational Safety and Health (NIOSH).

[ICSC-2] 1 2 3 4 5 6 7 8 Propyleneimine International Chemical Safety Card at actrav.itcilo.org

[3] "Propylene imine". Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).

[4] Malik, N.; Wiwattanapatapee, R.; Klopsch, R.; Lorenz, K.; Frey, H.; Weener, J. W.; Meijer, E. W.; Paulus, W.; Duncan, R. (2000). "Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labeled polyamidoamine dendrimers in vivo". Journal of Controlled Release. 65: 133–148. doi:10.1016/S0168-3659(99)00246-1.