Picornavirus internal ribosome entry site (IRES)

Picornavirus internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Picorna
Identifiers
Symbol IRES_Picorna
Rfam RF00229
Other data
RNA type Cis-reg; IRES
Domain(s) Viruses
GO 0043022
SO 0000243
PDB structures PDBe

This family represents the Picornavirus internal ribosome entry site (IRES). IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.[1][2]

References

  1. ↑ Ray, PS; Das S (2002). "La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA". Nucleic Acids Res. 30 (20): 4500&ndash, 4508. doi:10.1093/nar/gkf583. PMC 137146. PMID 12384597.
  2. ↑ Liu, Z; Carthy CM; Cheung P; Bohunek L; Wilson JE; McManus BM; Yang D (1999). "Structural and functional analysis of the 5' untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants". Virology. 265 (2): 206&ndash, 217. doi:10.1006/viro.1999.0048. PMID 10600593.
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