Phosphopantetheine

Phosphopantetheine
Skeletal formula of
Space-filling model of the phosphopantetheine molecule as an anion (2- charge)
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
DrugBank
MeSH phosphopantetheine
Properties
C11H23N2O7PS
Molar mass 358.349 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Phosphopantetheine, also known as 4'-Phosphopantetheine, is an essential prosthetic group of acyl carrier protein (ACP) and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) derived from Coenzyme A.[1] It is also present in formyltetrahydrofolate dehydrogenase.[2]

Functions

Phosphopantetheine fulfills two demands.

  • First, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich thiol ester linkage.
  • Second, the flexibility and length of phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme active sites.

See also

References

  1. ↑ Elovson J, Vagelos PR (July 1968). "Acyl carrier protein. X. Acyl carrier protein synthetase". J. Biol. Chem. 243 (13): 3603–11. PMID 4872726.
  2. ↑ Strickland KC, Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA (January 2010). "Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase". J. Biol. Chem. 285 (3): 1627–33. doi:10.1074/jbc.M109.080556. PMC 2804320. PMID 19933275.


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