Phosphatidylcholine—retinol O-acyltransferase
| phosphatidylcholine-retinol O-acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.135 | ||||||||
| CAS number | 117444-03-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a phosphatidylcholine---retinol O-acyltransferase (EC 2.3.1.135) is an enzyme that catalyzes the chemical reaction
- phosphatidylcholine + retinol---[cellular-retinol-binding-protein] 2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein]
Thus, the two substrates of this enzyme are phosphatidylcholine and [[retinol---[cellular-retinol-binding-protein]]], whereas its two products are 2-acylglycerophosphocholine and [[retinyl-ester---[cellular-retinol-binding-protein]]].
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase. Other names in common use include lecithin---retinol acyltransferase, phosphatidylcholine:retinol-(cellular-retinol-binding-protein), and O-acyltransferase.
References
- MacDonald PN, Ong DE (1988). "Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine". J. Biol. Chem. 263 (25): 12478&ndash, 82. PMID 3410848.
- Saari JC, Bredberg DL (1989). "Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes". J. Biol. Chem. 264 (15): 8636&ndash, 40. PMID 2722792.