Phenylpiperidine

Phenylpiperidine is a chemical compound with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated with phenylpiperidines including morphine-like activity^[1] or other central nervous system effects.

"Phenyl"piperidines
Compound	N	4-position	3-position	4'-position	Type of Pharmacology
MPPP	Me	Ph	H	-OCOEt	opioid analgesic
Prodine	Me	Ph	Me	-OCOEt	opioid analgesic
PEPAP	CH₂CH₂Ph	Ph	H	-OCOMe	opioid analgesic
Pethidine	Me	Ph	H	-CO₂Et	mu-agonist with SRI properties
Budipine	t-Bu	Ph	H	Ph	antiparkinson agent
Ketobemidone	Me	3-HO-Ph	H	-COEt	opioid + NMDA antagonist
Paroxetine	H	4-F-Ph	-CH₂OAr	H	SSRI (+ NET)
Femoxetine	Me	Ph	-CH₂O(4-MeOPh)	H	(S)SRI
CPCA	Me	4-Cl-Ph	-CO₂Me	H	monoamine reuptake inhibitor

Ar = benzodioxol-3-yl

Methylphenidate is a benzylpiperidine.

References

↑ Janssen, PA (April 1962). "A Review of the Chemical Features Associated with Strong Morphine-Like Activity". British Journal of Anaesthesia. 34 (4): 260–268. doi:10.1093/bja/34.4.260. PMID 14451235.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Janssen, PA (April 1962). "A Review of the Chemical Features Associated with Strong Morphine-Like Activity". British Journal of Anaesthesia. 34 (4): 260–268. doi:10.1093/bja/34.4.260. PMID 14451235.