Permanent cell

Permanent cells are cells that are incapable of regeneration. These cells are considered to be terminally differentiated and non proliferative in postnatal life. This includes brain cells, neurons, heart cells, skeletal muscle cells,[1] and red blood cells.[2]

Culture of rat brain cells stained with antibody to MAP2 (green), Neurofilament NF-H (red) and DNA (blue). MAP2 is found in neuronal dendrites, while the neurofilament is found predominantly in axons. Antibodies and image courtesy of EnCor Biotechnology

Disease and virology studies can use permanent cells to maintain cell count and accurately quantify the effects of vaccines.[1] Some embryology studies also use permanent cells to avoid harvesting embryonic cells from pregnant animals; since the cells are permanent, they may be harvested at a later age when an animal is fully developed.[3]

References

  1. 1 2 Schumacher, D (2002). "Generation of a permanent cell line that supports efficient growth of Marek's disease virus (MDV) by constitutive expression of MDV glycoprotein E.". Junior Genetic Virology. 83 (8): 1987–1992. doi:10.1099/0022-1317-83-8-1987. PMID 12124462.
  2. ↑ http://www.britannica.com/EBchecked/topic/452210/permanent-cell
  3. ↑ Seiler, AE; Spielmann, H (16 June 2011). "The validated embryonic stem cell test to predict embryotoxicity in vitro". Nature Protocols. 6 (7): 961–978. doi:10.1038/nprot.2011.348. PMID 21720311.
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