Paul Sigler

Paul B. Sigler
Born (1934-02-19)February 19, 1934[1][2]
Richmond, VA[3]
Died January 11, 2000(2000-01-11) (aged 65)[1][2]
New Haven, CT[3]
Cause of death arrhythmia[3]
Burial place Coop Prairie Cemetery, Mansfield, Arkansas[1]
35°03′54″N 94°14′13″W / 35.06500°N 94.23690°W / 35.06500; -94.23690[1]
Monuments Memorial plaque on Science Hill (Yale University)
Residence New Haven, CT
Chicago
Washington, DC
Cambridge, UK
New York City
Princeton, NJ
Buffalo, NY
Richmond, VA[3]
Nationality United States
Occupation Professor[4]
Spouse(s) Althea Jo Martin Sigler[3]
Children 5 children[3]
Parents
  • George Sigler (father)
  • Florence Kaminsky (mother)
Alma mater Princeton University
Columbia University (MD)
Cambridge University (PhD)[3]
Known for Phospholipase A2
trp repressor[2]
Awards National Academy of Sciences[3]
HHMI Investigator[5]
Guggenheim Fellow[3]
Helen Hay Whitney Fellow[6]
Scientific career
Fields Biophysics
Biochemistry[4]
Institutions Yale University[4]
University of Chicago
MRC-LMB
NIH[3]
Doctoral advisors David M. Blow[7]
Website www.hhmi.org/scientists/paul-b-sigler

Paul B. Sigler (February 19, 1934 – January 11, 2000[1][2]) was the Henry Ford II Professor of Molecular Biophysics and Biochemistry at Yale University.[4][8] Major awards included membership in the National Academy of Sciences, HHMI Investigator status, and Guggenheim[3] and Helen Hay Whitney Fellowships.[6] He is noted for pioneering studies of Phospholipase A2 and trp repressor amongst many others.[2]

Biography

Prior to coming to Yale, he was a professor at the University of Chicago.[3] He received his MD from Columbia University in 1959 and his undergraduate degree from Princeton University in 1955.[3] After briefly practicing medicine and working as a researcher for the NIH,[6] he would go on to earn a second doctorate, a PhD, from Cambridge University at the Laboratory of Molecular Biology[3] working under David M. Blow[7] before moving to the University of Chicago.[3]

Memorials

A memorial plaque is located in front of the Bass Center for Structural Bilogy on Science Hill on the campus of Yale University. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry.[9] Yale also has sponsored Paul Sigler memorial symposia in the past.[10] The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006.[11] He is buried at Coop Prairie Cemetery in Mansfield, Arkansas.[1]

Selected publications

  • Lambright, David G.; Sondek, John; Bohm, Andrew; Skiba, Nikolai P.; Hamm, Heidi E.; Sigler, Paul B. (1996). "The 2.0 Å crystal structure of a heterotrimeric G protein". Nature. 379 (6563): 311. doi:10.1038/379311a0. PMID 8552184.
  • Luisi, B. F.; Xu, W. X.; Otwinowski, Z.; Freedman, L. P.; Yamamoto, K. R.; Sigler, P. B. (1991). "Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA". Nature. 352 (6335): 497. doi:10.1038/352497a0. PMID 1865905.
  • Braig, Kerstin; Otwinowski, Zbyszek; Hegde, Rashmi; Boisvert, David C.; Joachimiak, Andrzej; Horwich, Arthur L.; Sigler, Paul B. (1994). "The crystal structure of the bacterial chaperonln GroEL at 2.8 Å". Nature. 371 (6498): 578. doi:10.1038/371578a0. PMID 7935790.
  • Kim, Youngchang; Geiger, James. H.; Hahn, Steven; Sigler, Paul B. (1993). "TBP". Nature. 365 (6446): 512. doi:10.1038/365512a0. PMID 8413604.
  • Vinson, C.; Sigler, P.; McKnight, S. (1989). "Scissors-grip model for DNA recognition by a family of leucine zipper proteins". Science. 246 (4932): 911. doi:10.1126/science.2683088. PMID 2683088.
  • Otwinowski, Z; Schevitz, R. W.; Zhang, R. G.; Lawson, C. L.; Joachimiak, A; Marmorstein, R. Q.; Luisi, B. F.; Sigler, P. B. (1988). "Crystal structure of trp repressor/operator complex at atomic resolution". Nature. 335 (6188): 321–9. doi:10.1038/335321a0. PMID 3419502.

See also

References

  1. 1 2 3 4 5 6 Paul B. Sigler at Find a Grave
  2. 1 2 3 4 5 "(IUCr) Paul B. Sigler (1934-2000)".
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 "New York Times Obit".
  4. 1 2 3 4 "Yale University Press Release".
  5. ↑ "Paul B. Sigler, MD, PhD - HHMI.org". HHMI.org.
  6. 1 2 3 "Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology".
  7. 1 2 "Blow on AcademicTree.org".
  8. ↑ "Official Site".
  9. ↑ Paul Sigler Memorial
  10. ↑ "Paul Sigler Symposium".
  11. ↑ "Helen Hay Whitney Foundation - Announcement".

Further reading

  • "New York Times Obit".
  • "Yale obit".
  • "(IUCr) Paul B. Sigler (1934-2000)".
  • "Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology".
  • Brian W. Matthews (2000). "Obituary: Paul Sigler (1934–2000)". Nature. 403 (6772): 848. doi:10.1038/35002722.
  • Henderson, Richard (2000). "Paul Sigler: A structural biologist with passion". Nature Structural Biology. 7 (4): 271. doi:10.1038/74024.
  • Jeruzalmi, David; Kuriyan, John; Doudna, Jennifer (2000). "Paul Sigler (1934–2000)". Trends in Biochemical Sciences. 25 (5): 221. doi:10.1016/S0968-0004(00)01587-5.
  • Horwich, A; Joachimiak, A (2000). "Paul Sigler (1934–2000)". Protein Science. 9 (4): 827–828. PMC 2144625.
  • Perutz, Max (2000). "Paul Sigler (1934–2000)". Cell. 101 (1): 23–4. doi:10.1016/S0092-8674(02)71111-2. PMID 10778852.
  • Davies, David R (2000). "Obituary: Paul Sigler". Structure. 8 (3): R67–8. doi:10.1016/S0969-2126(00)00113-1. PMID 10745016.
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