Paolo Zamboni
Paolo Zamboni | |
---|---|
Paolo Zamboni | |
Born |
Ferrara, Italy | 25 March 1957
Citizenship | Italy |
Awards | ISNVD Gold Medal |
Scientific career | |
Fields | Vascular surgery |
Institutions | Ferrara, Italy |
Paolo Zamboni (born 25 March 1957, Ferrara, Italy) is an Italian doctor who claims to have found in an unblinded preliminary study that in over 90% of the participants with multiple sclerosis there were problems in veins draining their brain, like stenosis or defective valves.[1] He also noticed high level of accumulation of iron deposits in the brain, supposedly due to restricted outflow of blood.[2]
According to Zamboni some symptoms of multiple sclerosis in his own wife as well as 73% of his patients abated after an endovascular procedure to open these veins.[3][4][5]
Zamboni named this condition chronic cerebrospinal venous insufficiency (CCSVI).[6]
The theory was controversial. The National Multiple Sclerosis Society had said that, while "there is not yet enough evidence to conclude that obstruction of veins causes MS," that "[Zamboni's] hypothesis on CCSVI and its corrective treatment is a path that must be more fully explored and one that we are supporting with research funding."[7] Since 2010, there has been more research that disputes the Zamboni theory.[8][9]
On November 28, 2017, Zamboni admitted that his treatment is largely ineffective on the basis of "a double-blind randomized controlled trial in which neither patients nor the researchers assessing whether there were improvements post-treatment knew which patients got the actual procedure and which received a sham therapy."[10]
References
- ↑ "Sclerosi multipla: la speranza viene da Ferrara? | NN - Notizie dall'Italia e dal Mondo dal 2009". Newnotizie.it. 14 January 2010. Retrieved 7 September 2013.
- ↑ Singh AV, Zamboni P (December 2009). "Anomalous venous blood flow and iron deposition in multiple sclerosis". J. Cereb. Blood Flow Metab. 29 (12): 1867–78. doi:10.1038/jcbfm.2009.180. PMID 19724286.
- ↑ Picard, André; Favaro, Avis (20 November 2009). "Researcher's labour of love leads to MS breakthrough". The Globe and Mail. Toronto.
- ↑ "W5: A whole new approach to MS | CTV News". Ctv.ca. Retrieved 7 September 2013.
- ↑ Archived January 23, 2010, at the Wayback Machine.
- ↑ "The Liberation Treatment: A whole new approach to MS" (FLV, Web page). CTV Television Network, W5. 2009. Retrieved 2009-12-10.
- ↑ "CCSVI and MS FAQ". National Multiple Sclerosis Society. Archived from the original on 22 February 2014. Retrieved 8 February 2014.
- ↑ "Massive study disputes Zamboni theory of multiple sclerosis". The Globe and Mail. 10 August 2010.
- ↑ Traboulsee AL. (2013). "Prevalence of extracranial venous narrowing on catheter venography in people with multiple sclerosis, their siblings, and unrelated healthy controls: a blinded, case-control study" (pdf). The Lancet. 383 (9912): 138–145. doi:10.1016/S0140-6736(13)61747-X. PMID 24119384.
- ↑ Branswell H. Scientist concedes his controversial MS therapy, once a source of great hope, is ‘largely ineffective’ StatNews:Health. November 28, 2017
External links
- Multiple Sclerosis Treatment and the CCSVI Scam
- Brief CV Paolo Zamboni, MD on Hilarescere Foundation
- Paolo Zamboni research profile on BiomedExperts