PTPRCAP

PTPRCAP
Identifiers
AliasesPTPRCAP, CD45-AP, LPAP, protein tyrosine phosphatase, receptor type C associated protein
External IDsMGI: 97811 HomoloGene: 48358 GeneCards: PTPRCAP
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.2Start67,435,510 bp[1]
End67,438,067 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5790

19265

Ensembl

ENSG00000213402

n/a

UniProt

Q14761

Q64697

RefSeq (mRNA)

NM_005608

NM_016933

RefSeq (protein)

NP_005599

NP_058629

Location (UCSC)Chr 11: 67.44 – 67.44 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Protein tyrosine phosphatase receptor type C-associated protein is an enzyme that in humans is encoded by the PTPRCAP gene.[4]

The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein.[4]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000213402 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. 1 2 "Entrez Gene: PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein".

Further reading

  • Schraven B, Schoenhaut D, Bruyns E, et al. (1994). "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes". J. Biol. Chem. 269 (46): 29102–11. PMID 7961877.
  • Bruyns E, Hendricks-Taylor LR, Meuer S, et al. (1996). "Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45". J. Biol. Chem. 270 (52): 31372–6. doi:10.1074/jbc.270.52.31372. PMID 8537410.
  • Bruyns E, Mincheva A, Bruyns RM, et al. (1997). "Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes". Genomics. 38 (1): 79–83. doi:10.1006/geno.1996.0595. PMID 8954783.
  • Kung C, Okumura M, Seavitt JR, et al. (2000). "CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction". Eur. J. Immunol. 29 (12): 3951–5. doi:10.1002/(SICI)1521-4141(199912)29:12<3951::AID-IMMU3951>3.0.CO;2-9. PMID 10602003.
  • Woods ML, Kivens WJ, Adelsman MA, et al. (2001). "A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor". EMBO J. 20 (6): 1232–44. doi:10.1093/emboj/20.6.1232. PMC 145515. PMID 11250890.
  • Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Vogel A, Strassburg CP, Manns MP (2003). "77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link". Genes Immun. 4 (1): 79–81. doi:10.1038/sj.gene.6363918. PMID 12595907.
  • Cocco E, Murru MR, Melis C, et al. (2004). "PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients". J. Neurol. 251 (9): 1085–8. doi:10.1007/s00415-004-0485-1. PMID 15372250.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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