PRINS (gene)

PRINS
Identifiers
AliasesPRINS, NCRNA00074, psoriasis associated non-protein coding RNA induced by stress
External IDsGeneCards: PRINS
Orthologs
SpeciesHumanMouse
Entrez

100169750

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

PRINS (psoriasis associated RNA induced by stress) is a long non-coding RNA. Its expression is induced by stress, and it may have a protective role in cells exposed to stress. It is over-expressed in the skin of patients with psoriasis.[2] It regulates G1P3, a gene encoding a protein with anti-apoptotic effects in keratinocytes. Overexpression of PRINS may contribute to psoriasis via the down-regulation of G1P3.[3]

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ Sonkoly E, Bata-Csorgo Z, Pivarcsi A, et al. (June 2005). "Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS". J. Biol. Chem. 280 (25): 24159–67. doi:10.1074/jbc.M501704200. PMID 15855153.
  3. ↑ Szegedi K, Sonkoly E, Nagy N, et al. (March 2010). "The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS". Exp. Dermatol. 19 (3): 269–78. doi:10.1111/j.1600-0625.2010.01066.x. PMID 20377629.

Further reading

  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.