PRB4

PRB4
Identifiers
AliasesPRB4, Po, proline-rich protein BstNI subfamily 4, proline rich protein BstNI subfamily 4
External IDsGeneCards: PRB4
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.2Start11,307,083 bp[1]
End11,310,435 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5545

n/a

Ensembl

ENSG00000274839
ENSG00000230657

n/a

UniProt

P10163

n/a

RefSeq (mRNA)

NM_002723
NM_001261399

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 12: 11.31 – 11.31 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene.[3]

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.[3]

PRB4 is post-translationally cleaved into three different mature peptides:

  • Protein N1
  • Glycosylated protein A
  • Peptide P-D (also known as proline-rich peptide IB-5)

References

  1. 1 2 3 ENSG00000230657 GRCh38: Ensembl release 89: ENSG00000274839, ENSG00000230657 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. 1 2 "Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4".

Further reading

  • Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their polymorphisms". Adv. Hum. Genet. 17: 141–99. doi:10.1007/978-1-4613-0987-1_5. PMID 3055850.
  • Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092.
  • Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics. 120 (1): 267–78. PMC 1203497. PMID 2851479.
  • Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. PMID 2993301.
  • Lyons KM, Azen EA, Goodman PA, Smithies O (1989). "Many Protein Products from a Few Loci: Assignment of Human Salivary Proline-Rich Proteins to Specific Loci". Genetics. 120 (1): 255–65. PMC 1203496. PMID 3220251.
  • Warner TF, Azen EA (1984). "Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract". Am. Rev. Respir. Dis. 130 (1): 115–8. PMID 6377992.
  • Saitoh E, Isemura S, Sanada K (1983). "Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva". J. Biochem. 93 (2): 495–502. doi:10.1093/jb/93.3.883. PMID 6841349.
  • Kauffman DL, Keller PJ, Bennick A, Blum M (1993). "Alignment of amino acid and DNA sequences of human proline-rich proteins". Crit. Rev. Oral Biol. Med. 4 (3–4): 287–92. PMID 8373986.
  • Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499.
  • Azen EA, Amberger E, Fisher S, et al. (1996). "PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins". Am. J. Hum. Genet. 58 (1): 143–53. PMC 1914931. PMID 8554050.
  • Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC 25286. PMID 9487127.
  • Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Vallat JM, Magy L, Lagrange E, et al. (2007). "Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance". Acta Neuropathol. 113 (4): 443–9. doi:10.1007/s00401-007-0196-7. PMID 17294201.


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