PPP1R2

PPP1R2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPP1R2, IPP-2, IPP2, protein phosphatase 1 regulatory inhibitor subunit 2, PPP1R2A
External IDsMGI: 1914099 HomoloGene: 4546 GeneCards: PPP1R2
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q29Start195,514,425 bp[1]
End195,543,386 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5504

66849

Ensembl

ENSG00000184203

ENSMUSG00000047714

UniProt

P41236

Q9DCL8

RefSeq (mRNA)

NM_001291504
NM_001291505
NM_006241
NM_001316325

NM_025800

RefSeq (protein)

NP_001278433
NP_001278434
NP_001303254
NP_006232

NP_080076

Location (UCSC)Chr 3: 195.51 – 195.54 MbChr 16: 31.25 – 31.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase inhibitor 2 is an enzyme that in humans is encoded by the PPP1R2 gene.[5][6][7]

Interactions

PPP1R2 has been shown to interact with LMTK2[8] and PPP1R9B.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000184203 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047714 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Permana PA, Mott DM (May 1997). "Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians". Genomics. 41 (1): 110–4. doi:10.1006/geno.1997.4649. PMID 9126490.
  6. ↑ Helps NR, Street AJ, Elledge SJ, Cohen PT (Apr 1994). "Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli". FEBS Lett. 340 (1–2): 93–8. doi:10.1016/0014-5793(94)80179-7. PMID 8119416.
  7. ↑ "Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2".
  8. ↑ Wang, Hong; Brautigan David L (Dec 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. Biol. Chem. United States. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. ISSN 0021-9258. PMID 12393858.
  9. ↑ Terry-Lorenzo, Ryan T; Elliot Elizabeth; Weiser Douglas C; Prickett Todd D; Brautigan David L; Shenolikar Shirish (Nov 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. United States. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. ISSN 0021-9258. PMID 12270929.

Further reading

  • Sanséau P, Jackson A, Alderton RP, et al. (1994). "Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences". Mamm. Genome. 5 (8): 490–6. doi:10.1007/BF00369318. PMID 7949733.
  • Park IK, Roach P, Bondor J, et al. (1994). "Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2". J. Biol. Chem. 269 (2): 944–54. PMID 8288648.
  • Kakinoki Y, Somers J, Brautigan DL (1998). "Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle". J. Biol. Chem. 272 (51): 32308–14. doi:10.1074/jbc.272.51.32308. PMID 9405437.
  • Yang J, Hurley TD, DePaoli-Roach AA (2000). "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif". J. Biol. Chem. 275 (30): 22635–44. doi:10.1074/jbc.M003082200. PMID 10807923.
  • Agarwal-Mawal A, Paudel HK (2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2". J. Biol. Chem. 276 (26): 23712–8. doi:10.1074/jbc.M010002200. PMID 11320080.
  • Eto M, Elliott E, Prickett TD, Brautigan DL (2003). "Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation". J. Biol. Chem. 277 (46): 44013–20. doi:10.1074/jbc.M208035200. PMID 12221103.
  • Terry-Lorenzo RT, Elliot E, Weiser DC, et al. (2003). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. PMID 12270929.
  • Wang H, Brautigan DL (2003). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. Biol. Chem. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. PMID 12393858.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
  • Leach C, Shenolikar S, Brautigan DL (2003). "Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis". J. Biol. Chem. 278 (28): 26015–20. doi:10.1074/jbc.M300782200. PMID 12697755.
  • Sakashita G, Shima H, Komatsu M, et al. (2004). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". J. Biochem. 133 (2): 165–71. doi:10.1093/jb/mvg020. PMID 12761178.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  • Yamada M, Ikeda Y, Yano M, et al. (2006). "Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy". FASEB J. 20 (8): 1197–9. doi:10.1096/fj.05-5299fje. PMID 16627625.
  • King TD, Gandy JC, Bijur GN (2007). "The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels". Exp. Cell Res. 312 (18): 3693–700. doi:10.1016/j.yexcr.2006.08.010. PMC 1885546. PMID 16987514.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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