PPM1F

PPM1F
Identifiers
Aliases	PPM1F, CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2, protein phosphatase, Mg2+/Mn2+ dependent 1F
External IDs	MGI: 1918464 HomoloGene: 22828 GeneCards: PPM1F
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	21,952,837 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	16,927,364 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• phosphoprotein phosphatase activity; • calmodulin-dependent protein phosphatase activity; • metal ion binding; • protein binding; • catalytic activity; • cation binding; • hydrolase activity; • protein serine/threonine phosphatase activity;
Cellular component	• perinuclear region of cytoplasm; • cytosol; • macromolecular complex;
Biological process	• apoptotic process; • peptidyl-threonine dephosphorylation; • negative regulation of protein kinase activity; • protein dephosphorylation; • positive regulation of epithelial cell migration; • positive regulation of growth; • histone dephosphorylation; • intrinsic apoptotic signaling pathway; • cellular response to drug; • positive regulation of gene expression; • positive regulation of chemotaxis; • negative regulation of protein kinase activity by regulation of protein phosphorylation; • negative regulation of peptidyl-serine phosphorylation; • positive regulation of focal adhesion assembly; • negative regulation of transcription, DNA-templated; • positive regulation of stress fiber assembly; • positive regulation of cell-substrate adhesion; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	9647
	68606
	ENSG00000100034
	ENSMUSG00000026181
	P49593
	Q8CGA0
	NM_014634
	NM_176833
	NP_055449
	NP_789803
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100034 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026181 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Koh CG, Tan EJ, Manser E, Lim L (Feb 2002). "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family". Curr Biol. 12 (4): 317–21. doi:10.1016/S0960-9822(02)00652-8. PMID 11864573.
↑ Tan KM, Chan SL, Tan KO, Yu VC (Nov 2001). "The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis". J Biol Chem. 276 (47): 44193–202. doi:10.1074/jbc.M105880200. PMID 11559703.
1 2 "Entrez Gene: PPM1F protein phosphatase 1F (PP2C domain containing)".

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
Kawasaki K, Minoshima S, Nakato E, et al. (1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus". Genome Res. 7 (3): 250–61. doi:10.1101/gr.7.3.250. PMID 9074928.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
Harvey BP, Banga SS, Ozer HL (2004). "Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts". J. Biol. Chem. 279 (23): 24889–98. doi:10.1074/jbc.M400656200. PMID 15140879.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100034 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026181 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid11864573-5] Koh CG, Tan EJ, Manser E, Lim L (Feb 2002). "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family". Curr Biol. 12 (4): 317–21. doi:10.1016/S0960-9822(02)00652-8. PMID 11864573.

[pmid11559703-6] Tan KM, Chan SL, Tan KO, Yu VC (Nov 2001). "The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis". J Biol Chem. 276 (47): 44193–202. doi:10.1074/jbc.M105880200. PMID 11559703.

[entrez-7] 1 2 "Entrez Gene: PPM1F protein phosphatase 1F (PP2C domain containing)".

PPM1F

References

Further reading