POLDIP3

POLDIP3
Identifiers
AliasesPOLDIP3, PDIP46, SKAR, polymerase (DNA) delta interacting protein 3, DNA polymerase delta interacting protein 3, PDIP3
External IDsMGI: 1921076 HomoloGene: 13007 GeneCards: POLDIP3
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.2Start42,583,721 bp[1]
End42,614,962 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

84271

73826

Ensembl

ENSG00000100227

ENSMUSG00000041815

UniProt

Q9BY77
Q8WUT1

Q8BG81

RefSeq (mRNA)

NM_001278657
NM_032311
NM_178136
NM_001363052

NM_178627
NM_001347082

RefSeq (protein)

NP_001265586
NP_115687
NP_835237
NP_001349981

NP_001334011
NP_848742

Location (UCSC)Chr 22: 42.58 – 42.61 MbChr 15: 83.13 – 83.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.[5][6]

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.[6]

Interactions

POLDIP3 has been shown to interact with P70-S6 Kinase 1.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100227 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041815 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
  6. 1 2 "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3".
  7. ↑ Richardson, Celeste J; Bröenstrup Mark; Fingar Diane C; Jülich Kristina; Ballif Bryan A; Gygi Steven; Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. England. 14 (17): 1540–9. doi:10.1016/j.cub.2004.08.061. ISSN 0960-9822. PMID 15341740.

Further reading

  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
  • Richardson CJ, Bröenstrup M, Fingar DC, et al. (2005). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. 14 (17): 1540–9. doi:10.1016/j.cub.2004.08.061. PMID 15341740.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  • Smyk A, Szuminska M, Uniewicz KA, et al. (2006). "Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth". FEBS J. 273 (20): 4728–41. doi:10.1111/j.1742-4658.2006.05477.x. PMID 16984396.


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