PLD5

PLD5
Identifiers
AliasesPLD5, PLDC, phospholipase D family member 5
External IDsMGI: 2442056 HomoloGene: 16081 GeneCards: PLD5
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q43Start242,082,986 bp[1]
End242,524,696 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

200150

319455

Ensembl

ENSG00000180287

ENSMUSG00000055214

UniProt

Q8N7P1

Q3UNN8

RefSeq (mRNA)

NM_001195811
NM_001195812
NM_152666
NM_001320272

RefSeq (protein)

NP_001182740
NP_001182741
NP_001307201
NP_689879

Location (UCSC)Chr 1: 242.08 – 242.52 MbChr 1: 175.96 – 176.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phospholipase D family, member 5 is a protein that in humans is encoded by the PLD5 gene.[5]

Model organisms

Model organisms have been used in the study of PLD5 function. A conditional knockout mouse line, called Pld5tm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000180287 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055214 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: PLD5 phospholipase D family, member 5". Retrieved 2011-12-04.
  6. ↑ "Salmonella infection data for Pld5". Wellcome Trust Sanger Institute.
  7. ↑ "Citrobacter infection data for Pld5". Wellcome Trust Sanger Institute.
  8. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  9. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. ↑ "International Knockout Mouse Consortium".
  11. ↑ "Mouse Genome Informatics".
  12. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  15. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

  • Anney, R.; Klei, L.; Pinto, D.; Regan, R.; Conroy, J.; Magalhaes, T. R.; Correia, C.; Abrahams, B. S.; Sykes, N.; Pagnamenta, A. T.; Almeida, J.; Bacchelli, E.; Bailey, A. J.; Baird, G.; Battaglia, A.; Berney, T.; Bolshakova, N.; Bölte, S.; Bolton, P. F.; Bourgeron, T.; Brennan, S.; Brian, J.; Carson, A. R.; Casallo, G.; Casey, J.; Chu, S. H.; Cochrane, L.; Corsello, C.; Crawford, E. L.; Crossett, A. (2010). "A genome-wide scan for common alleles affecting risk for autism". Human Molecular Genetics. 19 (20): 4072–4082. doi:10.1093/hmg/ddq307. PMC 2947401. PMID 20663923.
  • Rose, J.; Behm, F.; Drgon, T.; Johnson, C.; Uhl, G. R. (2010). "Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score". Molecular Medicine. 16 (7–8): 247–253. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • McCauley, J. L.; Zuvich, R. L.; Bradford, Y.; Kenealy, S. J.; Schnetz-Boutaud, N.; Gregory, S. G.; Hauser, S. L.; Oksenberg, J. R.; Mortlock, D. P.; Pericak-Vance, M. A.; Haines, J. L. (2009). "Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis". Genes and Immunity. 10 (7): 624–630. doi:10.1038/gene.2009.53. PMC 2765552. PMID 19626040.


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