PKIG

PKIG
Identifiers
AliasesPKIG, PKI-gamma, protein kinase (cAMP-dependent, catalytic) inhibitor gamma, cAMP-dependent protein kinase inhibitor gamma
External IDsMGI: 1343086 HomoloGene: 5133 GeneCards: PKIG
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.12Start44,531,785 bp[1]
End44,624,247 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11142

18769

Ensembl

ENSG00000168734

ENSMUSG00000035268

UniProt

Q9Y2B9

O70139

RefSeq (mRNA)

NM_181805
NM_001281444
NM_001281445
NM_007066
NM_181804

RefSeq (protein)

NP_001268373
NP_001268374
NP_008997
NP_861520
NP_861521

Location (UCSC)Chr 20: 44.53 – 44.62 MbChr 2: 163.66 – 163.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene.[5][6]

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000168734 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035268 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
  6. 1 2 "Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma".

Further reading

  • Collins SP, Uhler MD (1997). "Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase". J. Biol. Chem. 272 (29): 18169–78. doi:10.1074/jbc.272.29.18169. PMID 9218452.
  • Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
  • Lum H, Hao Z, Gayle D, et al. (2002). "Vascular endothelial cells express isoforms of protein kinase A inhibitor". Am. J. Physiol., Cell Physiol. 282 (1): C59–66. doi:10.1152/ajpcell.00256.2001. PMID 11742798.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
  • Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhao L, Yang S, Zhou GQ, et al. (2006). "Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation". Int. J. Biochem. Cell Biol. 38 (12): 2064–73. doi:10.1016/j.biocel.2006.05.015. PMID 16870489.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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