PHLDB2

PHLDB2
Identifiers
Aliases	PHLDB2, LL5b, LL5beta, pleckstrin homology like domain family B member 2
External IDs	MGI: 2444981 HomoloGene: 17100 GeneCards: PHLDB2
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	111,976,517 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	45,953,598 bp[2]
Gene ontology
Molecular function	• protein binding; • cadherin binding;
Cellular component	• plasma membrane; • intermediate filament cytoskeleton; • basal cortex; • cell leading edge; • membrane; • focal adhesion; • cytoplasm; • cytosol;
Biological process	• negative regulation of wound healing, spreading of epidermal cells; • regulation of epithelial to mesenchymal transition; • regulation of microtubule cytoskeleton organization; • positive regulation of basement membrane assembly involved in embryonic body morphogenesis; • negative regulation of stress fiber assembly; • regulation of gastrulation; • microtubule cytoskeleton organization; • negative regulation of focal adhesion assembly; • establishment of protein localization;
	Sources:Amigo / QuickGO
Orthologs
	90102
	208177
	ENSG00000144824
	ENSMUSG00000033149
	Q86SQ0
	Q8K1N2
	NM_145753; NM_001134437; NM_001134438; NM_001134439
	NM_001252442; NM_153412; NM_001357078
	NP_001127909; NP_001127910; NP_001127911; NP_665696
	NP_001239371; NP_700461; NP_001344007
	Wikidata
View/Edit Human	View/Edit Mouse

Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene.^[5]^[6]

Interactions

PHLDB2 has been shown to interact with FLNC.^[5]

1 2 3 GRCh38: Ensembl release 89: ENSG00000144824 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033149 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Paranavitane V, Coadwell WJ, Eguinoa A, Hawkins PT, Stephens L (Jan 2003). "LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin". J Biol Chem. 278 (2): 1328–35. doi:10.1074/jbc.M208352200. PMID 12376540.
↑ "Entrez Gene: PHLDB2 pleckstrin homology-like domain, family B, member 2".

Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (October 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A (July 2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y (May 2010). "Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta". J. Cell Biol. 189 (5): 901–17. doi:10.1083/jcb.200910095. PMC 2878951. PMID 20513769.

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