PHF2

PHF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KQI, 3PTR, 3PU3, 3PU8, 3PUA, 3PUS
Identifiers
Aliases	PHF2, CENP-35, GRC5, JHDM1E, PHD finger protein 2, KDM7C
External IDs	MGI: 1338034 HomoloGene: 3934 GeneCards: PHF2
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	93,679,587 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	48,871,119 bp[2]
Gene ontology
Molecular function	• iron ion binding; • histone demethylase activity (H3-K9 specific); • transcription coactivator activity; • dioxygenase activity; • metal ion binding; • methylated histone binding; • protein binding; • oxidoreductase activity; • histone demethylase activity; • zinc ion binding;
Cellular component	• condensed chromosome kinetochore; • nucleoplasm; • chromosome; • nucleolus; • chromosome, centromeric region; • kinetochore; • cell nucleus;
Biological process	• regulation of transcription, DNA-templated; • histone H3-K9 demethylation; • protein demethylation; • transcription, DNA-templated; • negative regulation of chromatin silencing at rDNA; • liver development; • oxidation-reduction process; • chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	5253
	18676
	ENSG00000197724
	ENSMUSG00000038025
	O75151
	Q9WTU0
	NM_005392; NM_024517
	NM_011078
	NP_005383
	NP_035208
	Wikidata
View/Edit Human	View/Edit Mouse

PHD finger protein 2 is a protein that in humans is encoded by the PHF2 gene. ^[5]

Function

This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197724 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038025 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: PHD finger protein 2". Retrieved 2016-04-09.

Sinha S, Singh RK, Alam N, Roy A, Roychoudhury S, Panda CK (2008). "Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma". Mol. Cancer. 7: 84. doi:10.1186/1476-4598-7-84. PMC 2633285. PMID 18990233.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197724 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038025 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: PHD finger protein 2". Retrieved 2016-04-09.

PHF2

Function

References

Further reading