PFKFB1

PFKFB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
External IDsMGI: 107816 HomoloGene: 105654 GeneCards: PFKFB1
Gene location (Human)
Chr.X chromosome (human)[1]
BandXp11.21Start54,932,961 bp[1]
End54,998,534 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5207

18639

Ensembl

ENSG00000158571

ENSMUSG00000025271

UniProt

P16118

P70266

RefSeq (mRNA)

NM_001271804
NM_001271805
NM_002625

NM_008824

RefSeq (protein)

NP_001258733
NP_001258734
NP_002616

NP_032850

Location (UCSC)Chr X: 54.93 – 55 MbChr X: 150.59 – 150.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.[5][6]

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000158571 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025271 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Batra RS, Hatchwell E, Rider S, Brown R, Brown GK, Craig IW (Apr 1997). "Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21". Genomics. 40 (2): 358–61. doi:10.1006/geno.1996.4530. PMID 9119406.
  6. 1 2 "Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1".

Further reading

  • Lange AJ, Pilkis SJ (1990). "Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". Nucleic Acids Res. 18 (12): 3652. doi:10.1093/nar/18.12.3652. PMC 331036. PMID 2163524.
  • Marker AJ, Colosia AD, Tauler A, et al. (1989). "Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression". J. Biol. Chem. 264 (12): 7000–4. PMID 2540168.
  • Algaier J, Uyeda K (1988). "Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase". Biochem. Biophys. Res. Commun. 153 (1): 328–33. doi:10.1016/S0006-291X(88)81226-9. PMID 2837207.
  • Lee YH, Li Y, Uyeda K, Hasemann CA (2003). "Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". J. Biol. Chem. 278 (1): 523–30. doi:10.1074/jbc.M209105200. PMID 12379646.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.