PERP

PERP
Identifiers
AliasesPERP, KCP1, KRTCAP1, PIGPC1, THW, dJ496H19.1, TP53 apoptosis effector
External IDsMGI: 1929938 HomoloGene: 11098 GeneCards: PERP
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q23.3Start138,088,505 bp[1]
End138,107,511 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64065

64058

Ensembl

ENSG00000112378

ENSMUSG00000019851

UniProt

Q96FX8

Q9JK95

RefSeq (mRNA)

NM_022121

NM_022032

RefSeq (protein)

NP_071404

NP_071315

Location (UCSC)Chr 6: 138.09 – 138.11 MbChr 10: 18.85 – 18.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

p53 apoptosis effector related to PMP-22 is a protein that in humans is encoded by the PERP gene.[5][6]

PERP is a direct transcriptional target of p53.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112378 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019851 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Hildebrandt T, Preiherr J, Tarbe N, Klostermann S, Van Muijen GN, Weidle UH (Dec 2000). "Identification of THW, a putative new tumor suppressor gene". Anticancer Res. 20 (5A): 2801–9. PMID 11062687.
  6. ↑ "Entrez Gene: PERP PERP, TP53 apoptosis effector".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Attardi LD, Reczek EE, Cosmas C, et al. (2000). "PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family". Genes Dev. 14 (6): 704–18. PMC 316461. PMID 10733530.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol. 148 (4): 654–64. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ihrie RA, Attardi LD (2004). "Perp-etrating p53-dependent apoptosis". Cell Cycle. 3 (3): 267–9. doi:10.4161/cc.3.3.722. PMID 14726658.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.


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