PECI (gene)

ECI2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQU, 2F6Q, 4U18, 4U19, 4U1A
Identifiers
Aliases	ECI2, ACBD2, DRS-1, DRS1, HCA88, PECI, dJ1013A10.3, enoyl-CoA delta isomerase 2
External IDs	MGI: 1346064 HomoloGene: 38145 GeneCards: ECI2
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	4,135,597 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	35,027,096 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• intramolecular oxidoreductase activity, transposing C=C bonds; • receptor binding; • catalytic activity; • isomerase activity; • fatty-acyl-CoA binding; • dodecenoyl-CoA delta-isomerase activity;
Cellular component	• membrane; • mitochondrion; • intracellular membrane-bounded organelle; • nucleoplasm; • peroxisomal matrix; • peroxisome;
Biological process	• fatty acid catabolic process; • fatty acid beta-oxidation; • metabolism; • fatty acid beta-oxidation using acyl-CoA oxidase;
	Sources:Amigo / QuickGO
Orthologs
	10455
	23986
	ENSG00000198721
	ENSMUSG00000021417
	O75521
	Q9WUR2
	NM_001166010; NM_006117; NM_206836
	NM_001110331; NM_001110332; NM_011868
	NP_001159482; NP_006108; NP_996667
	NP_001103801; NP_035998
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisomal 3,2-trans-enoyl-CoA isomerase is an enzyme that in humans is encoded by the PECI gene.^[5]^[6]

PECI is an auxiliary enzyme that catalyzes an isomerization step required for the beta-oxidation of unsaturated fatty acids.[supplied by OMIM]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198721 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021417 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Geisbrecht BV, Zhang D, Schulz H, Gould SJ (Aug 1999). "Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes". J Biol Chem. 274 (31): 21797–803. doi:10.1074/jbc.274.31.21797. PMID 10419495.
1 2 "Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Suk K, Kim YH, Hwang DY, et al. (1999). "Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor". Biochim. Biophys. Acta. 1454 (1): 126–31. doi:10.1016/s0925-4439(99)00033-2. PMID 10354522.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
Janssen U, Stoffel W (2002). "Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse". J. Biol. Chem. 277 (22): 19579–84. doi:10.1074/jbc.M110993200. PMID 11916962.
Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. doi:10.4049/jimmunol.169.2.1102. PMID 12097419.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Feng X, Chuhjo T, Sugimori C, et al. (2004). "Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells". Blood. 104 (8): 2425–31. doi:10.1182/blood-2004-05-1839. PMID 15217832.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198721 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021417 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10419495-5] Geisbrecht BV, Zhang D, Schulz H, Gould SJ (Aug 1999). "Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes". J Biol Chem. 274 (31): 21797–803. doi:10.1074/jbc.274.31.21797. PMID 10419495.

[entrez-6] 1 2 "Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase".

PECI (gene)

References

Further reading