PDLIM4

PDLIM4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDLIM4, RIL, PDZ and LIM domain 4
External IDsMGI: 1353470 HomoloGene: 2735 GeneCards: PDLIM4
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q31.1Start132,257,671 bp[1]
End132,273,454 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8572

30794

Ensembl

ENSG00000131435

ENSMUSG00000020388

UniProt

P50479

P70271

RefSeq (mRNA)

NM_003687
NM_001131027

NM_019417

RefSeq (protein)

NP_001124499
NP_003678

NP_062290

Location (UCSC)Chr 5: 132.26 – 132.27 MbChr 11: 54.05 – 54.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PDZ and LIM domain protein 4 is a protein that in humans is encoded by the PDLIM4 gene.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000131435 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020388 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Bashirova AA, Markelov ML, Shlykova TV, Levshenkova EV, Alibaeva RA, Frolova EI (Jun 1998). "The human RIL gene: mapping to human chromosome 5q31.1, genomic organization and alternative transcripts". Gene. 210 (2): 239–45. doi:10.1016/S0378-1119(98)00080-8. PMID 9573374.
  6. ↑ "Entrez Gene: PDLIM4 PDZ and LIM domain 4".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Cuppen E, van Ham M, Wansink DG, et al. (2000). "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL". Eur. J. Cell Biol. 79 (4): 283–93. doi:10.1078/S0171-9335(04)70031-X. PMID 10826496.
  • Walma T, Spronk CA, Tessari M, et al. (2002). "Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL". J. Mol. Biol. 316 (5): 1101–10. doi:10.1006/jmbi.2002.5402. PMID 11884147.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Omasu F, Ezura Y, Kajita M, et al. (2003). "Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women". J. Hum. Genet. 48 (7): 342–5. doi:10.1007/s10038-003-0035-1. PMID 12908099.
  • Vallenius T, Scharm B, Vesikansa A, et al. (2004). "The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of alpha-actinin with F-actin". Exp. Cell Res. 293 (1): 117–28. doi:10.1016/j.yexcr.2003.09.004. PMID 14729062.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • van den Berk LC, van Ham MA, te Lindert MM, et al. (2005). "The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain". Mol. Biol. Rep. 31 (4): 203–15. doi:10.1007/s11033-005-1407-8. PMID 15663004.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Schwartz LM, Woloshin S, Birkmeyer JD (2005). "How do elderly patients decide where to go for major surgery? Telephone interview survey". BMJ. 331 (7520): 821. doi:10.1136/bmj.38614.449016.DE. PMC 1246083. PMID 16192286.
  • Boumber YA, Kondo Y, Chen X, et al. (2007). "RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis". Cancer Res. 67 (5): 1997–2005. doi:10.1158/0008-5472.CAN-06-3093. PMID 17332327.


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