PDE7B

PDE7B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LXW
Identifiers
Aliases	PDE7B, bA472E5.1, phosphodiesterase 7B
External IDs	MGI: 1352752 HomoloGene: 32194 GeneCards: PDE7B
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	136,195,574 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	20,725,078 bp[2]
Gene ontology
Molecular function	• 3',5'-cyclic-AMP phosphodiesterase activity; • phosphoric diester hydrolase activity; • hydrolase activity; • 3',5'-cyclic-nucleotide phosphodiesterase activity; • metal ion binding;
Cellular component	• cytosol;
Biological process	• cAMP catabolic process; • signal transduction; • chemical synaptic transmission; • G-protein coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	27115
	29863
	ENSG00000171408
	ENSMUSG00000019990
	Q9NP56
	Q9QXQ1
	NM_018945
	NM_013875; NM_001347366
	NP_061818
	NP_001334295; NP_038903
	Wikidata
View/Edit Human	View/Edit Mouse

PDE7B is a mammalian gene that encodes a 3'5'-cyclic nucleotide phosphodiesterase (PDE) that converts 3'5'-cyclic adenosine monophosphate (cAMP) to 5'AMP as part of cyclic nucleotide signaling pathways ^[5]^[6]. There are 21 PDE genes in mammals that are pharmacologically-grouped into 11 families based on their biochemical characteristics and sequence conservation. The PDE7 family is composed of PDEs encoded by two genes, PDE7A and PDE7B. These PDEs are highly specific for cAMP relative to cGMP.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171408 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019990 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hetman, J.M., Soderling, S.H., Glavas, N.A., and Beavo, J.A. (2000). Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc Natl Acad Sci U S A 97, 472-476.
↑ Sasaki, T., Kotera, J., Yuasa, K., and Omori, K. (2000). Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 271, 575-583.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171408 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019990 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[5] Hetman, J.M., Soderling, S.H., Glavas, N.A., and Beavo, J.A. (2000). Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc Natl Acad Sci U S A 97, 472-476.

[6] Sasaki, T., Kotera, J., Yuasa, K., and Omori, K. (2000). Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 271, 575-583.