PDE1C

PDE1C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDE1C, Hcam3, cam-PDE 1C, hCam-3, phosphodiesterase 1C
External IDsMGI: 108413 HomoloGene: 3682 GeneCards: PDE1C
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p14.3Start31,751,179 bp[1]
End32,299,329 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5137

18575

Ensembl

ENSG00000154678

ENSMUSG00000004347

UniProt

Q14123

Q64338

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 7: 31.75 – 32.3 MbChr 6: 56.07 – 56.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C is an enzyme that in humans is encoded by the PDE1C gene.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154678 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004347 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.
  6. ↑ "Entrez Gene: PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa".

Further reading

  • Vandeput F, Wolda SL, Krall J, et al. (2007). "Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes". J. Biol. Chem. 282 (45): 32749–57. doi:10.1074/jbc.M703173200. PMID 17726023.
  • Dolci S, Belmonte A, Santone R, et al. (2006). "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases". Biochem. Biophys. Res. Commun. 341 (3): 837–46. doi:10.1016/j.bbrc.2006.01.035. PMID 16455054.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Rybalkin SD, Rybalkina I, Beavo JA, Bornfeldt KE (2002). "Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation". Circ. Res. 90 (2): 151–7. doi:10.1161/hh0202.104108. PMID 11834707.
  • Yan C, Zhao AZ, Sonnenburg WK, Beavo JA (2001). "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis". Biol. Reprod. 64 (6): 1746–54. doi:10.1095/biolreprod64.6.1746. PMID 11369604.
  • Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.


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