PAIP2

PAIP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPAIP2, PAIP-2, PAIP2A, poly(A) binding protein interacting protein 2
External IDsMGI: 1915119 HomoloGene: 22978 GeneCards: PAIP2
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q31.2Start139,341,587 bp[1]
End139,369,720 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51247

67869

Ensembl

ENSG00000120727

ENSMUSG00000037058

UniProt

Q9ULR5
Q6FID7
Q9BPZ3

Q9D6V8

RefSeq (mRNA)

NM_001033112
NM_016480

NM_026420
NM_001357470
NM_001357471
NM_001357472
NM_001357473

RefSeq (protein)

NP_065192
NP_001028284
NP_057564

NP_080696
NP_001344399
NP_001344400
NP_001344401
NP_001344402

Location (UCSC)Chr 5: 139.34 – 139.37 MbChr 18: 35.6 – 35.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polyadenylate-binding protein-interacting protein 2 is a protein that in humans is encoded by the PAIP2 gene.[5][6][7]

Interactions

PAIP2 has been shown to interact with PABPC1.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000120727 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037058 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo RC, Burley SK, Sonenberg N (Feb 2001). "Translational repression by a novel partner of human poly(A) binding protein, Paip2". Mol. Cell. 7 (1): 205–16. doi:10.1016/S1097-2765(01)00168-X. PMID 11172725.
  6. ↑ Berlanga JJ, Baass A, Sonenberg N (Jul 2006). "Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B". RNA. 12 (8): 1556–68. doi:10.1261/rna.106506. PMC 1524897. PMID 16804161.
  7. ↑ "Entrez Gene: PAIP2 poly(A) binding protein interacting protein 2".
  8. ↑ Khaleghpour K, Kahvejian A, De Crescenzo G, Roy G, Svitkin YV, Imataka H, O'Connor-McCourt M, Sonenberg N (Aug 2001). "Dual interactions of the translational repressor Paip2 with poly(A) binding protein". Mol. Cell. Biol. 21 (15): 5200–13. doi:10.1128/MCB.21.15.5200-5213.2001. PMC 87244. PMID 11438674.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Kozlov G, Trempe JF, Khaleghpour K, Kahvejian A, Ekiel I, Gehring K (2001). "Structure and function of the C-terminal PABC domain of human poly(A)-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4409–13. doi:10.1073/pnas.071024998. PMC 31848. PMID 11287632.
  • Khaleghpour K, Kahvejian A, De Crescenzo G, Roy G, Svitkin YV, Imataka H, O'Connor-McCourt M, Sonenberg N (2001). "Dual interactions of the translational repressor Paip2 with poly(A) binding protein". Mol. Cell. Biol. 21 (15): 5200–13. doi:10.1128/MCB.21.15.5200-5213.2001. PMC 87244. PMID 11438674.
  • Gouyon F, Onesto C, Dalet V, Pages G, Leturque A, Brot-Laroche E (2003). "Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2". Biochem. J. 375 (Pt 1): 167–74. doi:10.1042/BJ20030661. PMC 1223656. PMID 12820898.
  • Onesto C, Berra E, Grépin R, Pagès G (2004). "Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA". J. Biol. Chem. 279 (33): 34217–26. doi:10.1074/jbc.M400219200. PMID 15175342.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Yoshida M, Yoshida K, Kozlov G, Lim NS, De Crescenzo G, Pang Z, Berlanga JJ, Kahvejian A, Gehring K, Wing SS, Sonenberg N (2006). "Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2". EMBO J. 25 (9): 1934–44. doi:10.1038/sj.emboj.7601079. PMC 1456944. PMID 16601676.


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