PAG1

PAG1
Identifiers
AliasesPAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
External IDsMGI: 2443160 HomoloGene: 10198 GeneCards: PAG1
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q21.13Start80,967,810 bp[1]
End81,112,068 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55824

94212

Ensembl

ENSG00000076641

ENSMUSG00000027508

UniProt

Q9NWQ8

Q3U1F9

RefSeq (mRNA)

NM_018440

NM_001195031
NM_053182

RefSeq (protein)

NP_060910

NP_001181960
NP_444412

Location (UCSC)Chr 8: 80.97 – 81.11 MbChr 3: 9.69 – 9.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.[5][6]

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.[6]

Interactions

PAG1 has been shown to interact with FYN,[5] C-src tyrosine kinase,[5] Sodium-hydrogen antiporter 3 regulator 1[7] and Abl gene.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000076641 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027508 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 3 Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Hilgert I, Cerny J, Drbal K, Kuramitsu Y, Kornacker B, Horejsi V, Schraven B (May 2000). "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". J Exp Med. 191 (9): 1591–604. doi:10.1084/jem.191.9.1591. PMC 2213442. PMID 10790433.
  6. 1 2 "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1".
  7. ↑ Brdicková, N; Brdicka T; Andera L; Spicka J; Angelisová P; Milgram S L; Horejsí V (Oct 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Lett. Netherlands. 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. ISSN 0014-5793. PMID 11684085.
  8. ↑ Wen, S T; Van Etten R A (Oct 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes Dev. UNITED STATES. 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. ISSN 0890-9369. PMC 316562. PMID 9334312.

Further reading

  • Wen ST, Van Etten RA (1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes Dev. 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. PMC 316562. PMID 9334312.
  • Brdicková N, Brdicka T, Andera L, et al. (2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Lett. 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. PMID 11684085.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011.
  • Jiang LQ, Feng X, Zhou W, et al. (2006). "Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation". Oncogene. 25 (40): 5495–506. doi:10.1038/sj.onc.1209554. PMID 16636672.
  • Takeuchi S (2007). "Expression and purification of human PAG, a transmembrane adapter protein using an insect cell expression system and its structure basis". Protein J. 25 (4): 295–9. doi:10.1007/s10930-006-9015-6. PMID 16947079.
  • Roberts AE, Araki T, Swanson KD, et al. (2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nat. Genet. 39 (1): 70–4. doi:10.1038/ng1926. PMID 17143285.
  • Smida M, Posevitz-Fejfar A, Horejsi V, et al. (2007). "A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation". Blood. 110 (2): 596–615. doi:10.1182/blood-2006-07-038752. PMID 17389760.


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