P4HTM

P4HTM
Identifiers
Aliases	P4HTM, EGLN4, HIFPH4, P4H-TM, PH-4, PH4, PHD4, prolyl 4-hydroxylase, transmembrane
External IDs	MGI: 1921693 HomoloGene: 41765 GeneCards: P4HTM
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	49,007,154 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	108,597,667 bp[2]
Gene ontology
Molecular function	• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; • iron ion binding; • L-ascorbic acid binding; • oxidoreductase activity; • dioxygenase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • metal ion binding; • calcium ion binding; • procollagen-proline 4-dioxygenase activity;
Cellular component	• integral component of membrane; • endoplasmic reticulum membrane; • endoplasmic reticulum; • membrane;
Biological process	• regulation of erythrocyte differentiation; • oxidation-reduction process; • peptidyl-proline hydroxylation to 4-hydroxy-L-proline;
	Sources:Amigo / QuickGO
Orthologs
	54681
	74443
	ENSG00000178467
	ENSMUSG00000006675
	Q9NXG6
	Q8BG58
	NM_017732; NM_177938; NM_177939
	NM_028944; NM_001357465
	NP_808807; NP_808808
	NP_083220; NP_001344394
	Wikidata
View/Edit Human	View/Edit Mouse

Prolyl 4-hydroxylase, transmembrane is a protein that in humans is encoded by the P4HTM gene. ^[5]

Function

The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178467 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006675 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Prolyl 4-hydroxylase, transmembrane". Retrieved 2017-10-03.

Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hütter J, Schramm M, Flamme I (2002). "Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors". Biochem. Biophys. Res. Commun. 296 (2): 343–9. PMID 12163023.
Hirsilä M, Koivunen P, Günzler V, Kivirikko KI, Myllyharju J (2003). "Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor". J. Biol. Chem. 278 (33): 30772–80. doi:10.1074/jbc.M304982200. PMID 12788921.
Pekkala M, Hieta R, Bergmann U, Kivirikko KI, Wierenga RK, Myllyharju J (2004). "The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues". J. Biol. Chem. 279 (50): 52255–61. doi:10.1074/jbc.M410007200. PMID 15456751.
Hirota K, Semenza GL (2005). "Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases". Biochem. Biophys. Res. Commun. 338 (1): 610–6. doi:10.1016/j.bbrc.2005.08.193. PMID 16154531.
Iwahashi M, Muragaki Y, Ino K (2012). "Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle". Reprod. Biol. Endocrinol. 10: 111. doi:10.1186/1477-7827-10-111. PMC 3566935. PMID 23241241.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178467 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006675 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: Prolyl 4-hydroxylase, transmembrane". Retrieved 2017-10-03.

P4HTM

Function

References

Further reading