Oxalosuccinic acid

Oxalosuccinic acid
Names
	IUPAC name 1-Oxopropane-1,2,3-tricarboxylic acid
Identifiers
CAS Number	1948-82-9 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:7815 ;
ChemSpider	947 ;
ECHA InfoCard	100.230.021
KEGG	C05379 ;
PubChem CID	972;
	InChI InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13) Key: UFSCUAXLTRFIDC-UHFFFAOYSA-N ; InChI=1/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13) Key: UFSCUAXLTRFIDC-UHFFFAOYAK;
	SMILES C(C(C(=O)C(=O)O)C(=O)O)C(=O)O;
Properties
Chemical formula	C6H6O7
Molar mass	190.108
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Oxalosuccinic acid is a substrate of the citric acid cycle. It is acted upon by isocitrate dehydrogenase. Salts and esters of oxalosuccinic acid are known as oxalosuccinates.

Oxalosuccinic acid/oxalosuccinate is an unstable 6-carbon intermediate in the tricarboxylic acid cycle. It's an alpha-keto compound, formed during the oxidative decarboxylation of isocitrate to alpha-ketoglutarate, which is catalyzed by the enzyme isocitrate dehydrogenase. Oxalosuccinate never leaves the active site of the enzyme, however; it's unstable and immediately undergoes decarboxylation to produce the 5-carbon compound, alpha-ketoglutarate.

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Citric acid cycle metabolic pathway
Acetyl-CoA + H₂O	Oxaloacetate NADH +H⁺ NAD⁺ Malate H₂O Fumarate FADH₂ FAD Succinate CoA + ATP (GTP) P_i + ADP (GDP) Succinyl-CoA
Acetyl-CoA + H₂O		NADH + H⁺ + CO₂
CoA		NAD⁺
	Citrate H₂O cis-Aconitate H₂O Isocitrate NAD(P)⁺ NAD(P)H + H⁺ Oxalosuccinate CO₂ 2-oxoglutarate